Entity Details

Name SYNGAP1
ID Q96PV0
Role substrate
Enzymatic Domains
PH 150-251
PROSITE-ProRule
C2 242-363
PROSITE-ProRule
Ras-GAP 459-667
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CAMK2ASYNGAP1Ser780MARGLNSsMDMARLPphosphorylation
up-regulates activity		14970204SIGNOR-262690
CDK5SYNGAP1–phosphorylation
up-regulates activity		26912996SIGNOR-279157
CAMK2ASYNGAP1Ser1073PPLQRGKsQQLTVSAphosphorylation
up-regulates activity		14970204SIGNOR-262687
CAMK2ASYNGAP1Ser1138PSITKQHsQTPSTLNphosphorylation
up-regulates activity		14970204SIGNOR-262688
CAMK2ASYNGAP1Ser779FMARGLNsSMDMARLphosphorylation
up-regulates activity		14970204SIGNOR-262689
CAMK2ASYNGAP1Thr1077RGKSQQLtVSAAQKPphosphorylation
up-regulates activity		15358237SIGNOR-262691
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CAMK2Aphosphorylation
up-regulates
→
SYNGAP1
PSer780		phosphorylation
up-regulates
→		SYNGAP114970204SIGNOR-262690
CAMK2Aphosphorylation
up-regulates
→
SYNGAP1
PSer1073		phosphorylation
up-regulates
→		SYNGAP114970204SIGNOR-262687
CAMK2Aphosphorylation
up-regulates
→
SYNGAP1
PSer1138		phosphorylation
up-regulates
→		SYNGAP114970204SIGNOR-262688
CAMK2Aphosphorylation
up-regulates
→
SYNGAP1
PSer779		phosphorylation
up-regulates
→		SYNGAP114970204SIGNOR-262689
CAMK2Aphosphorylation
up-regulates
→
SYNGAP1
PThr1077		phosphorylation
up-regulates
→		SYNGAP115358237SIGNOR-262691
Regulator Mechanism/Effect Target SIGNOR-ID
CAMK2Aphosphorylation
→
up-regulates activity 		SYNGAP1SIGNOR-262690
CDK5phosphorylation
→
up-regulates activity 		SYNGAP1SIGNOR-279157
CAMK2Aphosphorylation
→
up-regulates activity 		SYNGAP1SIGNOR-262687
CAMK2Aphosphorylation
→
up-regulates activity 		SYNGAP1SIGNOR-262688
CAMK2Aphosphorylation
→
up-regulates activity 		SYNGAP1SIGNOR-262689
CAMK2Aphosphorylation
→
up-regulates activity 		SYNGAP1SIGNOR-262691