Summary

Name SYNGAP1
Full Name Ras/Rap GTPase-activating protein SynGAP
Synonyms Neuronal RasGAP, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1 | KIAA1938
Primary ID Q96PV0
Links - -
Type protein
Relations 6
Pathways Glutamatergic synapse
Function Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SYNGAP1 0.441
Publications: 5 Organism: In Vitro
Pathways:Glutamatergic synapse
+ up-regulates activity img/direct-activation.png binding DLG4 0.62
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse