| Name | DLC1 |
| ID | Q96QB1 |
| Role | substrate |
| Enzymatic Domains |
SAM 448-515
Rho-GAP 1078-1284 PROSITE-ProRule
START 1314-1521 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | DLC1 | Ser766 | VTRTRSLsACNKRVG | phosphorylation unknown | 16338927 | SIGNOR-247997 |
| CDK5 | DLC1 | – | phosphorylation up-regulates activity | 25452387 | SIGNOR-279602 | |
| CDK5 | DLC1 | Ser946 | SVSPCPSsPKQIHLD | phosphorylation up-regulates activity | 25452387 | SIGNOR-276446 |
| PRKD1 | DLC1 | Ser1244 | NTLKRENsSPRVMQR | phosphorylation down-regulates | 21087603 | SIGNOR-169994 |
| CDK5 | DLC1 | Ser642 | DSFGSLPsPKELSSF | phosphorylation up-regulates activity | 25452387 | SIGNOR-276444 |
| CDK5 | DLC1 | Ser859 | RRENSSDsPKELKRR | phosphorylation up-regulates activity | 25452387 | SIGNOR-276445 |
| CDK5 | DLC1 | Ser557 | LEEFDVFsPKQDLVP | phosphorylation up-regulates activity | 25452387 | SIGNOR-276443 |
| AKT1 | DLC1 | Ser766 | VTRTRSLsACNKRVG | phosphorylation unknown | 16338927 | SIGNOR-252550 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | DLC1 PSer766 | phosphorylation down-regulates ⊣ | DLC1 | 16338927 | SIGNOR-247997 |
| CDK5 | phosphorylation up-regulates → | DLC1 PSer946 | phosphorylation up-regulates → | DLC1 | 25452387 | SIGNOR-276446 |
| PRKD1 | phosphorylation up-regulates → | DLC1 PSer1244 | phosphorylation down-regulates ⊣ | DLC1 | 21087603 | SIGNOR-169994 |
| CDK5 | phosphorylation up-regulates → | DLC1 PSer642 | phosphorylation up-regulates → | DLC1 | 25452387 | SIGNOR-276444 |
| CDK5 | phosphorylation up-regulates → | DLC1 PSer859 | phosphorylation up-regulates → | DLC1 | 25452387 | SIGNOR-276445 |
| CDK5 | phosphorylation up-regulates → | DLC1 PSer557 | phosphorylation up-regulates → | DLC1 | 25452387 | SIGNOR-276443 |
| AKT1 | phosphorylation up-regulates → | DLC1 PSer766 | phosphorylation down-regulates ⊣ | DLC1 | 16338927 | SIGNOR-252550 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → unknown | DLC1 | SIGNOR-247997 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-279602 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-276446 |
| PRKD1 | phosphorylation down-regulates | DLC1 | SIGNOR-169994 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-276444 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-276445 |
| CDK5 | phosphorylation → up-regulates activity | DLC1 | SIGNOR-276443 |
| AKT1 | phosphorylation → unknown | DLC1 | SIGNOR-252550 |