3.0
Summary
| Name |  DLC1View Modifications |
| Full Name | Rho GTPase-activating protein 7 |
| Synonyms | Deleted in liver cancer 1 protein, DLC-1, HP protein, Rho-type GTPase-activating protein 7, START domain-containing protein 12, StARD12, StAR-related lipid transfer protein 12 | ARHGAP7, KIAA1723, STARD12 |
| Primary ID | Q96QB1 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKD1 | down-regulates 
phosphorylation
|
DLC1 | 0.386 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 |
phosphorylation
|
DLC1 | 0.514 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | AKT |
phosphorylation
|
DLC1 | 0.2 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | DLC1 | down-regulates activity
binding
|
MYH9 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |