| Name | CAMKK2 |
| ID | Q96RR4 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 165-446 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CAMKK2 | Ser129 | ICPSLPYsPVSSPQS | phosphorylation down-regulates | 22778263 | SIGNOR-198134 |
| DAPK1 | CAMKK2 | Ser511 | RREERSLsAPGNLLT | phosphorylation down-regulates | 15209507 | SIGNOR-126241 |
| GSK3A | CAMKK2 | Ser133 | LPYSPVSsPQSSPRL | phosphorylation down-regulates | 22778263 | SIGNOR-198126 |
| PKA | CAMKK2 | Ser495 | KTMIRKRsFGNPFEG | phosphorylation down-regulates activity | 32913128 | SIGNOR-277238 |
| CDK5 | CAMKK2 | Ser133 | LPYSPVSsPQSSPRL | phosphorylation down-regulates | 22778263 | SIGNOR-198115 |
| GSK3A | CAMKK2 | Ser137 | PVSSPQSsPRLPRRP | phosphorylation down-regulates | 22778263 | SIGNOR-198130 |
| PKA | CAMKK2 | Ser511 | RREERSLsAPGNLLT | phosphorylation down-regulates | 22778263 | SIGNOR-198154 |
| GSK3A | CAMKK2 | Ser129 | ICPSLPYsPVSSPQS | phosphorylation down-regulates | 22778263 | SIGNOR-198122 |
| CDK5 | CAMKK2 | Ser137 | PVSSPQSsPRLPRRP | phosphorylation down-regulates | 22778263 | SIGNOR-197945 |
| CAMKK2 | CAMKK2 | Thr483 | KHIPSLAtVILVKTM | phosphorylation up-regulates | 22778263 | SIGNOR-198107 |
| CDK5 | CAMKK2 | Ser129 | ICPSLPYsPVSSPQS | phosphorylation down-regulates | 22778263 | SIGNOR-198111 |
| PKA | CAMKK2 | Ser495 | KTMIRKRsFGNPFEG | phosphorylation down-regulates | 22778263 | SIGNOR-198150 |
| DAPK1 | CAMKK2 | Ser511 | RREERSLsAPGNLLT | phosphorylation unknown | 15209507 | SIGNOR-126245 |
| GSK3B | CAMKK2 | Ser137 | PVSSPQSsPRLPRRP | phosphorylation down-regulates | 22778263 | SIGNOR-198142 |
| GSK3B | CAMKK2 | Ser133 | LPYSPVSsPQSSPRL | phosphorylation down-regulates | 22778263 | SIGNOR-198138 |
| PKA | CAMKK2 | Ser511 | RREERSLsAPGNLLT | phosphorylation down-regulates activity | 32913128 | SIGNOR-277240 |
| PKA | CAMKK2 | Ser100 | HLSGRKLsLQERSQG | phosphorylation down-regulates | 22778263 | SIGNOR-198146 |
| PKA | CAMKK2 | Ser100 | HLSGRKLsLQERSQG | phosphorylation down-regulates activity | 32913128 | SIGNOR-277239 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CAMKK2 PSer129 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198134 |
| DAPK1 | phosphorylation up-regulates → | CAMKK2 PSer511 | phosphorylation down-regulates ⊣ | CAMKK2 | 15209507 | SIGNOR-126241 |
| GSK3A | phosphorylation up-regulates → | CAMKK2 PSer133 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198126 |
| PKA | phosphorylation up-regulates → | CAMKK2 PSer495 | phosphorylation down-regulates ⊣ | CAMKK2 | 32913128 | SIGNOR-277238 |
| CDK5 | phosphorylation up-regulates → | CAMKK2 PSer133 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198115 |
| GSK3A | phosphorylation up-regulates → | CAMKK2 PSer137 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198130 |
| PKA | phosphorylation up-regulates → | CAMKK2 PSer511 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198154 |
| GSK3A | phosphorylation up-regulates → | CAMKK2 PSer129 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198122 |
| CDK5 | phosphorylation up-regulates → | CAMKK2 PSer137 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-197945 |
| CAMKK2 | phosphorylation up-regulates → | CAMKK2 PThr483 | phosphorylation up-regulates → | CAMKK2 | 22778263 | SIGNOR-198107 |
| CDK5 | phosphorylation up-regulates → | CAMKK2 PSer129 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198111 |
| PKA | phosphorylation up-regulates → | CAMKK2 PSer495 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198150 |
| DAPK1 | phosphorylation up-regulates → | CAMKK2 PSer511 | phosphorylation down-regulates ⊣ | CAMKK2 | 15209507 | SIGNOR-126245 |
| GSK3B | phosphorylation up-regulates → | CAMKK2 PSer137 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198142 |
| GSK3B | phosphorylation up-regulates → | CAMKK2 PSer133 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198138 |
| PKA | phosphorylation up-regulates → | CAMKK2 PSer511 | phosphorylation down-regulates ⊣ | CAMKK2 | 32913128 | SIGNOR-277240 |
| PKA | phosphorylation up-regulates → | CAMKK2 PSer100 | phosphorylation down-regulates ⊣ | CAMKK2 | 22778263 | SIGNOR-198146 |
| PKA | phosphorylation up-regulates → | CAMKK2 PSer100 | phosphorylation down-regulates ⊣ | CAMKK2 | 32913128 | SIGNOR-277239 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation down-regulates | CAMKK2 | SIGNOR-198134 |
| DAPK1 | phosphorylation down-regulates | CAMKK2 | SIGNOR-126241 |
| GSK3A | phosphorylation down-regulates | CAMKK2 | SIGNOR-198126 |
| PKA | phosphorylation → down-regulates activity | CAMKK2 | SIGNOR-277238 |
| CDK5 | phosphorylation down-regulates | CAMKK2 | SIGNOR-198115 |
| GSK3A | phosphorylation down-regulates | CAMKK2 | SIGNOR-198130 |
| PKA | phosphorylation down-regulates | CAMKK2 | SIGNOR-198154 |
| GSK3A | phosphorylation down-regulates | CAMKK2 | SIGNOR-198122 |
| CDK5 | phosphorylation down-regulates | CAMKK2 | SIGNOR-197945 |
| CAMKK2 | phosphorylation → up-regulates | CAMKK2 | SIGNOR-198107 |
| CDK5 | phosphorylation down-regulates | CAMKK2 | SIGNOR-198111 |
| PKA | phosphorylation down-regulates | CAMKK2 | SIGNOR-198150 |
| DAPK1 | phosphorylation → unknown | CAMKK2 | SIGNOR-126245 |
| GSK3B | phosphorylation down-regulates | CAMKK2 | SIGNOR-198142 |
| GSK3B | phosphorylation down-regulates | CAMKK2 | SIGNOR-198138 |
| PKA | phosphorylation → down-regulates activity | CAMKK2 | SIGNOR-277240 |
| PKA | phosphorylation down-regulates | CAMKK2 | SIGNOR-198146 |
| PKA | phosphorylation → down-regulates activity | CAMKK2 | SIGNOR-277239 |