Summary

Name CAMKK2
Full Name Calcium/calmodulin-dependent protein kinase kinase 2
Synonyms CaM-KK 2, CaM-kinase kinase 2, CaMKK 2, Calcium/calmodulin-dependent protein kinase kinase beta, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta | CAMKKB, KIAA0787
Primary ID Q96RR4
Links - -
Type protein
Relations 22
Function Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation CAMKK2 0.08
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CAMKK2 0.08
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CAMKK2 0.08
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CAMKK2 0.08
Publications: 3 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CAMKK2 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ img/unknown.png phosphorylation CAMKK2 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation PRKAA2 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CAMK1 0.41
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation PRKAA1 0.30
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CAMK4 0.41
Publications: 1
+ up-regulates img/direct-activation.png phosphorylation CAMKK2 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CAMKK2 0.08
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ up-regulates img/direct-activation.png phosphorylation AMPK 0.08
Publications: 1 Organism: Homo Sapiens