| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | PNKP | Ser114 | EETRTPEsQPDTPPG | phosphorylation up-regulates | 21824916 | SIGNOR-176008 |
| PRKDC | PNKP | Ser114 | EETRTPEsQPDTPPG | phosphorylation up-regulates | 21824916 | SIGNOR-176016 |
| ATM | PNKP | Ser126 | PPGTPLVsQDEKRDA | phosphorylation up-regulates | 21824916 | SIGNOR-176012 |
| PRKDC | PNKP | Ser126 | PPGTPLVsQDEKRDA | phosphorylation up-regulates | 21824916 | SIGNOR-176020 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | PNKP PSer114 | phosphorylation up-regulates → | PNKP | 21824916 | SIGNOR-176008 |
| PRKDC | phosphorylation up-regulates → | PNKP PSer114 | phosphorylation up-regulates → | PNKP | 21824916 | SIGNOR-176016 |
| ATM | phosphorylation up-regulates → | PNKP PSer126 | phosphorylation up-regulates → | PNKP | 21824916 | SIGNOR-176012 |
| PRKDC | phosphorylation up-regulates → | PNKP PSer126 | phosphorylation up-regulates → | PNKP | 21824916 | SIGNOR-176020 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → up-regulates | PNKP | SIGNOR-176008 |
| PRKDC | phosphorylation → up-regulates | PNKP | SIGNOR-176016 |
| ATM | phosphorylation → up-regulates | PNKP | SIGNOR-176012 |
| PRKDC | phosphorylation → up-regulates | PNKP | SIGNOR-176020 |
