| Name | KIF2C |
| ID | Q99661 |
| Role | substrate |
| Enzymatic Domains |
Kinesin motor 258-588 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | KIF2C | Thr537 | LGQNKAHtPFRESKL | phosphorylation down-regulates | 20368358 | SIGNOR-164761 |
| PLK1 | KIF2C | Ser633 | ELSSQMSsFNEAMTQ | phosphorylation up-regulates activity | 25504441 | SIGNOR-276861 |
| AURKB | KIF2C | Ser95 | IQKQKRRsVNSKIPA | phosphorylation up-regulates | 17567953 | SIGNOR-155890 |
| AURKB | KIF2C | Ser111 | KESLRSRsTRMSTVS | phosphorylation down-regulates | 17567953 | SIGNOR-155894 |
| PAK1 | KIF2C | Ser192 | VNSVRRKsCLVKEVE | phosphorylation down-regulates | 23055517 | SIGNOR-199084 |
| AURKB | KIF2C | Ser192 | VNSVRRKsCLVKEVE | phosphorylation down-regulates | 17567953 | SIGNOR-155898 |
| PLK1 | KIF2C | – | phosphorylation up-regulates activity | 21078677 | SIGNOR-278908 | |
| AURKA | KIF2C | Ser719 | EQASRQIsSKKRPQ | phosphorylation down-regulates activity | 18434591 | SIGNOR-279139 |
| PLK1 | KIF2C | Ser715 | MQLEEQAsRQISSKK | phosphorylation up-regulates activity | 26206521 | SIGNOR-276931 |
| PLK1 | KIF2C | Ser621 | ALIPGNLsKEEEELS | phosphorylation down-regulates quantity by destabilization | 25504441 | SIGNOR-276862 |
| PAK1 | KIF2C | Ser111 | KESLRSRsTRMSTVS | phosphorylation down-regulates | 23055517 | SIGNOR-199080 |
| PLK1 | KIF2C | Ser632 | EELSSQMsSFNEAMT | phosphorylation up-regulates activity | 25504441 | SIGNOR-276863 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | KIF2C PThr537 | phosphorylation down-regulates ⊣ | KIF2C | 20368358 | SIGNOR-164761 |
| PLK1 | phosphorylation up-regulates → | KIF2C PSer633 | phosphorylation up-regulates → | KIF2C | 25504441 | SIGNOR-276861 |
| AURKB | phosphorylation up-regulates → | KIF2C PSer95 | phosphorylation up-regulates → | KIF2C | 17567953 | SIGNOR-155890 |
| AURKB | phosphorylation up-regulates → | KIF2C PSer111 | phosphorylation down-regulates ⊣ | KIF2C | 17567953 | SIGNOR-155894 |
| PAK1 | phosphorylation up-regulates → | KIF2C PSer192 | phosphorylation down-regulates ⊣ | KIF2C | 23055517 | SIGNOR-199084 |
| AURKB | phosphorylation up-regulates → | KIF2C PSer192 | phosphorylation down-regulates ⊣ | KIF2C | 17567953 | SIGNOR-155898 |
| AURKA | phosphorylation up-regulates → | KIF2C PSer719 | phosphorylation down-regulates ⊣ | KIF2C | 18434591 | SIGNOR-279139 |
| PLK1 | phosphorylation up-regulates → | KIF2C PSer715 | phosphorylation up-regulates → | KIF2C | 26206521 | SIGNOR-276931 |
| PLK1 | phosphorylation up-regulates → | KIF2C PSer621 | phosphorylation down-regulates ⊣ | KIF2C | 25504441 | SIGNOR-276862 |
| PAK1 | phosphorylation up-regulates → | KIF2C PSer111 | phosphorylation down-regulates ⊣ | KIF2C | 23055517 | SIGNOR-199080 |
| PLK1 | phosphorylation up-regulates → | KIF2C PSer632 | phosphorylation up-regulates → | KIF2C | 25504441 | SIGNOR-276863 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation down-regulates | KIF2C | SIGNOR-164761 |
| PLK1 | phosphorylation → up-regulates activity | KIF2C | SIGNOR-276861 |
| AURKB | phosphorylation → up-regulates | KIF2C | SIGNOR-155890 |
| AURKB | phosphorylation down-regulates | KIF2C | SIGNOR-155894 |
| PAK1 | phosphorylation down-regulates | KIF2C | SIGNOR-199084 |
| AURKB | phosphorylation down-regulates | KIF2C | SIGNOR-155898 |
| PLK1 | phosphorylation → up-regulates activity | KIF2C | SIGNOR-278908 |
| AURKA | phosphorylation → down-regulates activity | KIF2C | SIGNOR-279139 |
| PLK1 | phosphorylation → up-regulates activity | KIF2C | SIGNOR-276931 |
| PLK1 | phosphorylation down-regulates quantity by destabilization | KIF2C | SIGNOR-276862 |
| PAK1 | phosphorylation down-regulates | KIF2C | SIGNOR-199080 |
| PLK1 | phosphorylation → up-regulates activity | KIF2C | SIGNOR-276863 |