Summary

Name KIF2C
Full Name Kinesin-like protein KIF2C
Synonyms Kinesin-like protein 6, Mitotic centromere-associated kinesin, MCAK | KNSL6
Primary ID Q99661
Links - -
Type protein
Relations 6
Function In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation KIF2C 0.22
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIF2C 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation KIF2C 0.22
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIF2C 0.14
Publications: 1 Organism: Homo Sapiens