| Name | MAP3K5 |
| ID | Q99683 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 680-938 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K5 | COX7A2L | – | phosphorylation up-regulates activity | 28039481 | SIGNOR-278341 | |
| MAP3K5 | MAP2K7 | – | phosphorylation up-regulates | 11959862 | SIGNOR-117264 | |
| MAP3K5 | MAP2K7 | – | phosphorylation up-regulates | 19920149 | SIGNOR-161766 | |
| MAP3K5 | MAP2K7 | – | phosphorylation up-regulates activity | 17110930 | SIGNOR-274148 | |
| MAP3K5 | ERN1 | – | phosphorylation up-regulates activity | 25249581 | SIGNOR-279213 | |
| MAP3K5 | CDKN1A | Ser98 | GGRRPGTsPALLQGT | phosphorylation up-regulates | 17325029 | SIGNOR-153440 |
| MAP3K5 | MAP2K4 | Thr261 | LVDSIAKtRDAGCRP | phosphorylation up-regulates activity | 8974401 | SIGNOR-45373 |
| MAP3K5 | MAP2K4 | – | phosphorylation up-regulates activity | 8974401 | SIGNOR-45366 | |
| MAP3K5 | MAP2K3 | Ser218 | ISGYLVDsVAKTMDA | phosphorylation up-regulates activity | 19920149 | SIGNOR-161763 |
| MAP3K5 | MAP2K3 | – | phosphorylation up-regulates activity | 8974401 | SIGNOR-226672 | |
| MAP3K5 | MAP2K6 | – | phosphorylation up-regulates activity | 8974401 | SIGNOR-45353 | |
| MAP3K5 | ZNF622 | Ser314 | WCNEKGKsFYSTEAV | phosphorylation up-regulates | 21771788 | SIGNOR-175113 |
| MAP3K5 | ZNF622 | Thr318 | KGKSFYStEAVQAHM | phosphorylation up-regulates | 21771788 | SIGNOR-175117 |
| MAP3K5 | MAP3K5 | Thr813 | GDNVLINtYSGVLKI | phosphorylation up-regulates activity | 17937911 | SIGNOR-158423 |
| MAP3K5 | MAP3K5 | Thr838 | GINPCTEtFTGTLQY | phosphorylation up-regulates activity | 17937911 | SIGNOR-158427 |
| MAP3K5 | MAP3K5 | Thr842 | CTETFTGtLQYMAPE | phosphorylation up-regulates activity | 17937911 | SIGNOR-158431 |
| MAP3K5 | DAXX | Ser176 | TNAENTAsQSPRTRG | phosphorylation up-regulates | 19789335 | SIGNOR-188321 |
| MAP3K5 | DAXX | Ser184 | QSPRTRGsRRQIQRL | phosphorylation up-regulates | 19789335 | SIGNOR-188325 |
| MAP3K5 | DAXX | Ser176 | TNAENTAsQSPRTRG | phosphorylation up-regulates quantity by stabilization | 19789335 | SIGNOR-109680 |
| MAP3K5 | DAXX | Ser184 | QSPRTRGsRRQIQRL | phosphorylation up-regulates quantity by stabilization | 19789335 | SIGNOR-109684 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K5 | phosphorylation up-regulates → | CDKN1A PSer98 | phosphorylation up-regulates → | CDKN1A | 17325029 | SIGNOR-153440 |
| MAP3K5 | phosphorylation up-regulates → | MAP2K4 PThr261 | phosphorylation up-regulates → | MAP2K4 | 8974401 | SIGNOR-45373 |
| MAP3K5 | phosphorylation up-regulates → | MAP2K3 PSer218 | phosphorylation up-regulates → | MAP2K3 | 19920149 | SIGNOR-161763 |
| MAP3K5 | phosphorylation up-regulates → | ZNF622 PSer314 | phosphorylation up-regulates → | ZNF622 | 21771788 | SIGNOR-175113 |
| MAP3K5 | phosphorylation up-regulates → | ZNF622 PThr318 | phosphorylation up-regulates → | ZNF622 | 21771788 | SIGNOR-175117 |
| MAP3K5 | phosphorylation up-regulates → | MAP3K5 PThr813 | phosphorylation up-regulates → | MAP3K5 | 17937911 | SIGNOR-158423 |
| MAP3K5 | phosphorylation up-regulates → | MAP3K5 PThr838 | phosphorylation up-regulates → | MAP3K5 | 17937911 | SIGNOR-158427 |
| MAP3K5 | phosphorylation up-regulates → | MAP3K5 PThr842 | phosphorylation up-regulates → | MAP3K5 | 17937911 | SIGNOR-158431 |
| MAP3K5 | phosphorylation up-regulates → | DAXX PSer176 | phosphorylation up-regulates → | DAXX | 19789335 | SIGNOR-188321 |
| MAP3K5 | phosphorylation up-regulates → | DAXX PSer184 | phosphorylation up-regulates → | DAXX | 19789335 | SIGNOR-188325 |
| MAP3K5 | phosphorylation up-regulates → | DAXX PSer176 | phosphorylation up-regulates → | DAXX | 19789335 | SIGNOR-109680 |
| MAP3K5 | phosphorylation up-regulates → | DAXX PSer184 | phosphorylation up-regulates → | DAXX | 19789335 | SIGNOR-109684 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K5 | phosphorylation → up-regulates activity | COX7A2L | SIGNOR-278341 |
| MAP3K5 | phosphorylation → up-regulates | MAP2K7 | SIGNOR-117264 |
| MAP3K5 | phosphorylation → up-regulates | MAP2K7 | SIGNOR-161766 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K7 | SIGNOR-274148 |
| MAP3K5 | phosphorylation → up-regulates activity | ERN1 | SIGNOR-279213 |
| MAP3K5 | phosphorylation → up-regulates | CDKN1A | SIGNOR-153440 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-45373 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K4 | SIGNOR-45366 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K3 | SIGNOR-161763 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K3 | SIGNOR-226672 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP2K6 | SIGNOR-45353 |
| MAP3K5 | phosphorylation → up-regulates | ZNF622 | SIGNOR-175113 |
| MAP3K5 | phosphorylation → up-regulates | ZNF622 | SIGNOR-175117 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-158423 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-158427 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-158431 |
| MAP3K5 | phosphorylation → up-regulates | DAXX | SIGNOR-188321 |
| MAP3K5 | phosphorylation → up-regulates | DAXX | SIGNOR-188325 |
| MAP3K5 | phosphorylation → up-regulates quantity by stabilization | DAXX | SIGNOR-109680 |
| MAP3K5 | phosphorylation → up-regulates quantity by stabilization | DAXX | SIGNOR-109684 |