Summary

Name MAP3K5
Full Name Mitogen-activated protein kinase kinase kinase 5
Synonyms Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5 | ASK1, MAPKKK5, MEKK5
Primary ID Q99683
Links - -
Type protein
Relations 57
Pathways P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation DAXX 0.841
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation DAXX 0.841
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.597
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ up-regulates img/direct-activation.png phosphorylation ZNF622 0.491
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.642
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.726
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.281
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.2
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation MAP3K5 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1A 0.587
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K4 0.629
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K5 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K5 0.326
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAP3K5 0.595
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ down-regulates img/direct_inhibition.png dephosphorylation MAP3K5 0.32
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ up-regulates activity img/direct-activation.png dephosphorylation MAP3K5 0.439
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K5 0.546
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation MAP3K5 0.546
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation MAP3K5 0.368
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.368
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation MAP3K5 0.368
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP3K5 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding MAP3K5 0.357
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding MAP3K5 0.396
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.609
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding MAP3K5 0.691
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP3K5 0.736
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, TNF-alpha Signaling
+ up-regulates img/direct-activation.png phosphorylation MAP3K5 0.254
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/direct-activation.png binding MAP3K5 0.841
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAP3K5 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling
+ up-regulates img/direct-activation.png phosphorylation MAP2K7 0.591
Publications: 2 Organism: Homo Sapiens
Pathways:TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K7 0.591
Publications: 1 Organism: Homo Sapiens
Pathways:TNF-alpha Signaling
+ up-regulates img/indirect-activation.png MAP3K5 0.37
Publications: 1 Organism: Mus Musculus
+ img/unknown.png binding MAP3K5 0.2
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates quantity by stabilization img/direct-activation.png dephosphorylation MAP3K5 0.368
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png MAP3K5 0.322
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding MAP3K5 0.357
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png phosphorylation COX7A2L 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAP3K5 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP3K5 0.837
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding MAP3K6 0.546
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAP3K5 0.29
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP3K5 0.2
Publications: 1 Organism: Homo Sapiens