Summary

Name MAP3K5
Full Name Mitogen-activated protein kinase kinase kinase 5
Synonyms Apoptosis signal-regulating kinase 1, ASK-1, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5 | ASK1, MAPKKK5, MEKK5
Primary ID Q99683
Links - -
Type protein
Relations 41
Pathways P38 Signaling, P38 Signaling and Myogenesis, TNF alpha
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation DAXX 0.75
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DAXX 0.75
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K3 0.45
Publications: 2 Organism: Homo Sapiens, Chlorocebus Aethiops
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF alpha
+ up-regulates img/direct-activation.png phosphorylation ZNF622 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.36
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation MAP3K5 0.15
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png dephosphorylation MAP3K5
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CDKN1A
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K4 0.82
Publications: 2 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF alpha
+ up-regulates activity img/direct-activation.png phosphorylation MAP3K5
Publications: 3 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF alpha
+ down-regulates img/direct_inhibition.png dephosphorylation MAP3K5 0.36
Publications: 1 Organism: Homo Sapiens
Tissue: Brain, Kidney
+ down-regulates activity img/direct_inhibition.png dephosphorylation MAP3K5 0.53
Publications: 2 Organism: Homo Sapiens, Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation MAP3K5 0.12
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png dephosphorylation MAP3K5 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation MAP3K5 0.45
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ up-regulates img/indirect-activation.png unknown MAP3K5 0.11
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP3K5
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding MAP3K5 0.16
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP3K5 0.58
Publications: 2 Organism: Homo Sapiens
Pathways:TNF alpha
+ up-regulates img/direct-activation.png phosphorylation MAP2K7 0.53
Publications: 2 Organism: Homo Sapiens
Pathways:TNF alpha
+ up-regulates activity img/direct-activation.png phosphorylation MAP2K6 0.64
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling, P38 Signaling and Myogenesis
+ up-regulates img/direct-activation.png binding MAP3K5 0.75
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding MAP3K5 0.11
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding MAP3K5
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ img/unknown.png binding MAP3K5
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding MAP3K5
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding MAP3K5 0.59
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png binding MAP3K5
Publications: 1 Organism: Mus Musculus
Pathways:P38 Signaling and Myogenesis
+ up-regulates img/indirect-activation.png unknown MAP3K5
Publications: 1 Organism: Homo Sapiens
Pathways:P38 Signaling