| Name | MAP3K5 |
| ID | Q99683 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 680-938 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN11 | MAP3K5 | – | dephosphorylation up-regulates quantity by stabilization | 19287004 | SIGNOR-276144 | |
| RPS6KA3 | MAP3K5 | Thr1109 | DRKIIATtLSKLKLE | phosphorylation down-regulates activity | 23608533 | SIGNOR-276463 |
| CDC25C | MAP3K5 | – | dephosphorylation down-regulates activity | 32518522 | SIGNOR-277100 | |
| LRRK2 | MAP3K5 | Thr825 | LKISDFGtSKRLAGI | phosphorylation up-regulates activity | 28888991 | SIGNOR-277251 |
| PPM1L | MAP3K5 | Thr838 | GINPCTEtFTGTLQY | dephosphorylation down-regulates | 17456047 | SIGNOR-154554 |
| PPP5C | MAP3K5 | Thr838 | GINPCTEtFTGTLQY | dephosphorylation down-regulates activity | 11689443 | SIGNOR-111301 |
| PIM1 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates | 19749799 | SIGNOR-187905 |
| JAK2 | MAP3K5 | Tyr718 | IPERDSRySQPLHEE | phosphorylation down-regulates | 19287004 | SIGNOR-184600 |
| RPS6KA3 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 23608533 | SIGNOR-276464 |
| MAP3K5 | MAP3K5 | Thr842 | CTETFTGtLQYMAPE | phosphorylation up-regulates activity | 17937911 | SIGNOR-158431 |
| DUSP12 | MAP3K5 | – | dephosphorylation down-regulates activity | 33811209 | SIGNOR-277032 | |
| PTPN11 | MAP3K5 | Tyr718 | IPERDSRySQPLHEE | dephosphorylation up-regulates | 19287004 | SIGNOR-184604 |
| MAP3K6 | MAP3K5 | Thr838 | GINPCTEtFTGTLQY | phosphorylation up-regulates quantity by stabilization | 17210579 | SIGNOR-260832 |
| AKT2 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 12697749 | SIGNOR-100588 |
| SLK | MAP3K5 | – | phosphorylation up-regulates | 16316999 | SIGNOR-142665 | |
| MELK | MAP3K5 | – | phosphorylation up-regulates activity | 24185907 | SIGNOR-280039 | |
| MAP3K5 | MAP3K5 | Thr838 | GINPCTEtFTGTLQY | phosphorylation up-regulates activity | 17937911 | SIGNOR-158427 |
| RPS6KA3 | MAP3K5 | Thr1326 | VNGADEDtISRFLAE | phosphorylation down-regulates activity | 23608533 | SIGNOR-276462 |
| MAP3K6 | MAP3K5 | Thr838 | GINPCTEtFTGTLQY | phosphorylation up-regulates activity | 17210579 | SIGNOR-260773 |
| PIM | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates | 19749799 | SIGNOR-259410 |
| DYRK1A | MAP3K5 | – | phosphorylation up-regulates activity | 22110360 | SIGNOR-279366 | |
| PGAM5 | MAP3K5 | Thr838 | GINPCTEtFTGTLQY | dephosphorylation up-regulates activity | 19590015 | SIGNOR-277984 |
| MAP3K5 | MAP3K5 | Thr813 | GDNVLINtYSGVLKI | phosphorylation up-regulates activity | 17937911 | SIGNOR-158423 |
| AKT | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 11154276 | SIGNOR-104646 |
| PPP5C | MAP3K5 | Thr842 | CTETFTGtLQYMAPE | dephosphorylation down-regulates activity | 11689443 | SIGNOR-248540 |
| PP2Ca_R1A_Bd | MAP3K5 | Ser966 | NEYLRSIsLPVPVLV | dephosphorylation up-regulates activity | 27858941 | SIGNOR-254756 |
| JAK2 | MAP3K5 | Tyr718 | IPERDSRySQPLHEE | phosphorylation down-regulates quantity by destabilization | 19287004 | SIGNOR-276145 |
| AKT1 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 11154276 | SIGNOR-252465 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KA3 | phosphorylation up-regulates → | MAP3K5 PThr1109 | phosphorylation down-regulates ⊣ | MAP3K5 | 23608533 | SIGNOR-276463 |
| LRRK2 | phosphorylation up-regulates → | MAP3K5 PThr825 | phosphorylation up-regulates → | MAP3K5 | 28888991 | SIGNOR-277251 |
| PPM1L | dephosphorylation down-regulates ⊣ | MAP3K5 PThr838 | dephosphorylation up-regulates → | MAP3K5 | 17456047 | SIGNOR-154554 |
| PPP5C | dephosphorylation down-regulates ⊣ | MAP3K5 PThr838 | dephosphorylation up-regulates → | MAP3K5 | 11689443 | SIGNOR-111301 |
| PIM1 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 19749799 | SIGNOR-187905 |
| JAK2 | phosphorylation up-regulates → | MAP3K5 PTyr718 | phosphorylation down-regulates ⊣ | MAP3K5 | 19287004 | SIGNOR-184600 |
| RPS6KA3 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 23608533 | SIGNOR-276464 |
| MAP3K5 | phosphorylation up-regulates → | MAP3K5 PThr842 | phosphorylation up-regulates → | MAP3K5 | 17937911 | SIGNOR-158431 |
| PTPN11 | dephosphorylation down-regulates ⊣ | MAP3K5 PTyr718 | dephosphorylation down-regulates ⊣ | MAP3K5 | 19287004 | SIGNOR-184604 |
| MAP3K6 | phosphorylation up-regulates → | MAP3K5 PThr838 | phosphorylation up-regulates → | MAP3K5 | 17210579 | SIGNOR-260832 |
| AKT2 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 12697749 | SIGNOR-100588 |
| MAP3K5 | phosphorylation up-regulates → | MAP3K5 PThr838 | phosphorylation up-regulates → | MAP3K5 | 17937911 | SIGNOR-158427 |
| RPS6KA3 | phosphorylation up-regulates → | MAP3K5 PThr1326 | phosphorylation down-regulates ⊣ | MAP3K5 | 23608533 | SIGNOR-276462 |
| MAP3K6 | phosphorylation up-regulates → | MAP3K5 PThr838 | phosphorylation up-regulates → | MAP3K5 | 17210579 | SIGNOR-260773 |
| PIM | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 19749799 | SIGNOR-259410 |
| PGAM5 | dephosphorylation down-regulates ⊣ | MAP3K5 PThr838 | dephosphorylation down-regulates ⊣ | MAP3K5 | 19590015 | SIGNOR-277984 |
| MAP3K5 | phosphorylation up-regulates → | MAP3K5 PThr813 | phosphorylation up-regulates → | MAP3K5 | 17937911 | SIGNOR-158423 |
| AKT | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 11154276 | SIGNOR-104646 |
| PPP5C | dephosphorylation down-regulates ⊣ | MAP3K5 PThr842 | dephosphorylation up-regulates → | MAP3K5 | 11689443 | SIGNOR-248540 |
| PP2Ca_R1A_Bd | dephosphorylation down-regulates ⊣ | MAP3K5 PSer966 | dephosphorylation down-regulates ⊣ | MAP3K5 | 27858941 | SIGNOR-254756 |
| JAK2 | phosphorylation up-regulates → | MAP3K5 PTyr718 | phosphorylation down-regulates ⊣ | MAP3K5 | 19287004 | SIGNOR-276145 |
| AKT1 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 11154276 | SIGNOR-252465 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN11 | dephosphorylation → up-regulates quantity by stabilization | MAP3K5 | SIGNOR-276144 |
| RPS6KA3 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-276463 |
| CDC25C | dephosphorylation → down-regulates activity | MAP3K5 | SIGNOR-277100 |
| LRRK2 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-277251 |
| PPM1L | dephosphorylation down-regulates | MAP3K5 | SIGNOR-154554 |
| PPP5C | dephosphorylation → down-regulates activity | MAP3K5 | SIGNOR-111301 |
| PIM1 | phosphorylation down-regulates | MAP3K5 | SIGNOR-187905 |
| JAK2 | phosphorylation down-regulates | MAP3K5 | SIGNOR-184600 |
| RPS6KA3 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-276464 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-158431 |
| DUSP12 | dephosphorylation → down-regulates activity | MAP3K5 | SIGNOR-277032 |
| PTPN11 | dephosphorylation → up-regulates | MAP3K5 | SIGNOR-184604 |
| MAP3K6 | phosphorylation → up-regulates quantity by stabilization | MAP3K5 | SIGNOR-260832 |
| AKT2 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-100588 |
| SLK | phosphorylation → up-regulates | MAP3K5 | SIGNOR-142665 |
| MELK | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-280039 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-158427 |
| RPS6KA3 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-276462 |
| MAP3K6 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-260773 |
| PIM | phosphorylation down-regulates | MAP3K5 | SIGNOR-259410 |
| DYRK1A | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-279366 |
| PGAM5 | dephosphorylation → up-regulates activity | MAP3K5 | SIGNOR-277984 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-158423 |
| AKT | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-104646 |
| PPP5C | dephosphorylation → down-regulates activity | MAP3K5 | SIGNOR-248540 |
| PP2Ca_R1A_Bd | dephosphorylation → up-regulates activity | MAP3K5 | SIGNOR-254756 |
| JAK2 | phosphorylation down-regulates quantity by destabilization | MAP3K5 | SIGNOR-276145 |
| AKT1 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-252465 |