| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 11154276 | SIGNOR-104646 |
| AKT1 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 11154276 | SIGNOR-252465 |
| PIM1 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates | 19749799 | SIGNOR-187905 |
| RPS6KA3 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 23608533 | SIGNOR-276464 |
| AKT2 | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates activity | 12697749 | SIGNOR-100588 |
| PIM | MAP3K5 | Ser83 | ATRGRGSsVGGGSRR | phosphorylation down-regulates | 19749799 | SIGNOR-259410 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AKT | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 11154276 | SIGNOR-104646 |
| AKT1 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 11154276 | SIGNOR-252465 |
| PIM1 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 19749799 | SIGNOR-187905 |
| RPS6KA3 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 23608533 | SIGNOR-276464 |
| AKT2 | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 12697749 | SIGNOR-100588 |
| PIM | phosphorylation up-regulates → | MAP3K5 PSer83 | phosphorylation down-regulates ⊣ | MAP3K5 | 19749799 | SIGNOR-259410 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AKT | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-104646 |
| AKT1 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-252465 |
| PIM1 | phosphorylation down-regulates | MAP3K5 | SIGNOR-187905 |
| RPS6KA3 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-276464 |
| AKT2 | phosphorylation → down-regulates activity | MAP3K5 | SIGNOR-100588 |
| PIM | phosphorylation down-regulates | MAP3K5 | SIGNOR-259410 |
