| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP5C | MAP3K5 | Thr842 | CTETFTGtLQYMAPE | dephosphorylation down-regulates activity | 11689443 | SIGNOR-248540 |
| MAP3K5 | MAP3K5 | Thr842 | CTETFTGtLQYMAPE | phosphorylation up-regulates activity | 17937911 | SIGNOR-158431 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PPP5C | dephosphorylation down-regulates ⊣ | MAP3K5 PThr842 | dephosphorylation up-regulates → | MAP3K5 | 11689443 | SIGNOR-248540 |
| MAP3K5 | phosphorylation up-regulates → | MAP3K5 PThr842 | phosphorylation up-regulates → | MAP3K5 | 17937911 | SIGNOR-158431 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PPP5C | dephosphorylation → down-regulates activity | MAP3K5 | SIGNOR-248540 |
| MAP3K5 | phosphorylation → up-regulates activity | MAP3K5 | SIGNOR-158431 |
