Entity Details

Name MAP3K5_Tyr718
ID Q99683
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
JAK2MAP3K5Tyr718IPERDSRySQPLHEEphosphorylation
down-regulates		19287004SIGNOR-184600
PTPN11MAP3K5Tyr718IPERDSRySQPLHEEdephosphorylation
up-regulates		19287004SIGNOR-184604
JAK2MAP3K5Tyr718IPERDSRySQPLHEEphosphorylation
down-regulates quantity by destabilization		19287004SIGNOR-276145
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
JAK2phosphorylation
up-regulates
→
MAP3K5
PTyr718		phosphorylation
down-regulates
⊣		MAP3K519287004SIGNOR-184600
PTPN11dephosphorylation
down-regulates
⊣
MAP3K5
PTyr718		dephosphorylation
down-regulates
⊣		MAP3K519287004SIGNOR-184604
JAK2phosphorylation
up-regulates
→
MAP3K5
PTyr718		phosphorylation
down-regulates
⊣		MAP3K519287004SIGNOR-276145
Regulator Mechanism/Effect Target SIGNOR-ID
JAK2phosphorylation
img/direct_inhibition.png
down-regulates 		MAP3K5SIGNOR-184600
PTPN11dephosphorylation
→
up-regulates 		MAP3K5SIGNOR-184604
JAK2phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MAP3K5SIGNOR-276145