Entity Details

Name SMAD5
ID Q99717
Role substrate
Enzymatic Domains
MH1 13-137
PROSITE-ProRule
MH2 271-465
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ROCK1SMAD5–phosphorylation
up-regulates activity		34285210SIGNOR-280107
BMPR1BSMAD5–phosphorylation
up-regulates activity		19620713SIGNOR-255260
BMPR1ASMAD5–phosphorylation
up-regulates activity		19620713SIGNOR-255261
ACVR1SMAD5–phosphorylation
up-regulates		9748228SIGNOR-60171
BMPR1ASMAD5–phosphorylation
up-regulates		19620713SIGNOR-187184
BMPR1BSMAD5–phosphorylation
up-regulates		19620713SIGNOR-187193
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
Regulator Mechanism/Effect Target SIGNOR-ID
ROCK1phosphorylation
→
up-regulates activity 		SMAD5SIGNOR-280107
BMPR1Bphosphorylation
→
up-regulates activity 		SMAD5SIGNOR-255260
BMPR1Aphosphorylation
→
up-regulates activity 		SMAD5SIGNOR-255261
ACVR1phosphorylation
→
up-regulates 		SMAD5SIGNOR-60171
BMPR1Aphosphorylation
→
up-regulates 		SMAD5SIGNOR-187184
BMPR1Bphosphorylation
→
up-regulates 		SMAD5SIGNOR-187193