| + |
ACVR1 | up-regulates 
|
SMAD5 |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236848 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10564272 |
We found that both smad6 and smad7 inhibit the activation of smad1 and smad5 by bmpr-ia/alk-3 and bmpr-ib/alk-6, as well as that by alk-2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ACVR1 | up-regulates 
phosphorylation
|
SMAD5 |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60171 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9748228 |
Bmp7 stimulated phosphorylation of endogenous smad1 and 5, formation of complexes with smad4 and induced the promoter for the homeobox gene, tlx2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | up-regulates
phosphorylation
|
SMAD4 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168737 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR1A | up-regulates activity
phosphorylation
|
SMAD5 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255261 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19620713 |
Two types of bmp-induced signaling pathways are known, the smad and p38 mapk pathways. In the former case, bmpr1 phosphorylates smad-1,-5,-8, which forms a complex with smad4 that translocates into the nucleus and regulates gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | up-regulates quantity
transcriptional regulation
|
GATA3 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268943 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMURF2 | down-regulates 
ubiquitination
|
SMAD5 |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-193378 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP2 | up-regulates
|
SMAD5 |
0.702 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195564 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Neogenin, a transmembranous protein, was re-ported to regulate bmp receptor association with lipid raft, where bmp induces canonical smad1/5/8 phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | form complex 
binding
|
SMAD5/SMAD4 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255266 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20957627 |
Whereas alk5 signalling is mediated by phosphorylation of smad2 and smad3 proteins, alk1 signalling is mediated by smad1, smad5, and smad8. Activated smads form a complex with the common smad (co-smad; smad4 in mammals) and shuttle into the nucleus. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255775 |
|
|
Homo sapiens |
C2C12 Cell, HEK-293-EBNA Cell, L-6 Myoblast Cell |
| pmid |
sentence |
| 9442019 |
These data suggest that activation of Smad5 and subsequent Smad5-DPC4 complex formation are key steps in the BMP signaling pathway, which mediates BMP-2-induced osteoblastic differentiation of the C2C12 mesenchymal cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | up-regulates quantity
transcriptional regulation
|
HAND1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268941 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
STUB1 | down-regulates
ubiquitination
|
SMAD5 |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
In ad-dition, some proteins (e.g. Chip, carboxyl terminus of hsc70-interacting protein) inhibit the signaling activi-ties of smad1/5 by recruiting smad1/5 from the functional r-/co-smad complex and further pro-moting the ubiquitination and degradation of smad1/5 in a chaperone-independent manne |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172996 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21454478 |
In addition, some proteins (e.g. Chip, carboxyl terminus of hsc70-interacting protein) inhibit the signaling activities of smad1/5 by recruiting smad1/5 from the functional r/co-smad complex and further promoting the ubiquitination and degradation of smad1/5 in a chaperone-independent manner |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
BMPR1B | up-regulates
|
SMAD5 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235625 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10564272 |
We found that both smad6 and smad7 inhibit the activation of smad1 and smad5 by bmpr-ia/alk-3 and bmpr-ib/alk-6, as well as that by alk-2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMURF2 | down-regulates quantity by destabilization
ubiquitination
|
SMAD5 |
0.737 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153420 |
|
|
Homo sapiens |
Osteoblast |
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Bone |
| + |
BMPR1B | up-regulates activity
phosphorylation
|
SMAD5 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255260 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19620713 |
Two types of bmp-induced signaling pathways are known, the smad and p38 mapk pathways. In the former case, bmpr1 phosphorylates smad-1,-5,-8, which forms a complex with smad4 that translocates into the nucleus and regulates gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ROCK1 | up-regulates activity
phosphorylation
|
SMAD5 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280107 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 34285210 |
The results showed that SMAD5 was directly phosphorylated at Ser463/465 by ROCK1 (Fig.\u00a04g).|These data indicated that the activation of SMAD5 induced by TEM8 was mediated directly by the RhoC/ROCK1 pathway.To evaluate the effect of SMAD5 on the cellular functions of TEM8, SMAD5 was knockdown in TEM8-overexpressing cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | up-regulates quantity
transcriptional regulation
|
SMAD6 |
0.6 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268940 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SKIL | down-regulates
binding
|
SMAD5 |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12419246 |
Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR1A | up-regulates
phosphorylation
|
SMAD5 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187184 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19620713 |
Two types of bmp-induced signaling pathways are known, the smad and p38 mapk pathways. In the former case, bmpr1 phosphorylates smad-1,-5,-8, which forms a complex with smad4 that translocates into the nucleus and regulates gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF | down-regulates
ubiquitination
|
SMAD5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270213 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degra-dation of smads and receptors for tgf-beta and bmps |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKI | down-regulates
binding
|
SMAD5 |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12419246 |
Ski also represses bmp signaling through interactions with smad4 and bmp-specific r-smads, smad1 or smad6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMURF1 | down-regulates
ubiquitination
|
SMAD5 |
0.77 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195663 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMPR1B | up-regulates
phosphorylation
|
SMAD5 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187193 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19620713 |
Two types of bmp-induced signaling pathways are known, the smad and p38 mapk pathways. In the former case, bmpr1 phosphorylates smad-1,-5,-8, which forms a complex with smad4 that translocates into the nucleus and regulates gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD5 | up-regulates
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242059 |
|
|
Mus musculus |
Ovarian Serous Carcinoma Cell |
| pmid |
sentence |
| 23993924 |
Engagement of BMP4-mediated signaling in adult mouse ovary-derived OSCs cultured in vitro drives differentiation of these cells into IVD oocytes through Smad1/5/8 activation and transcriptional up-regulation of key meiosis-initiating genes. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BMPR1A | up-regulates
|
SMAD5 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235361 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 10564272 |
We found that both smad6 and smad7 inhibit the activation of smad1 and smad5 by bmpr-ia/alk-3 and bmpr-ib/alk-6, as well as that by alk-2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD5 | up-regulates quantity
transcriptional regulation
|
GADD45G |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268942 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SMAD5 | up-regulates quantity
transcriptional regulation
|
SATB2 |
0.26 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268939 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22219353 |
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
SMAD5
- 
- 