Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MKNK1	SPRY2	Ser112	APLSRSIsTVSSGSR	phosphorylation down-regulates	19864419	SIGNOR-188889
MKNK1	SPRY2	Ser121	VSSGSRSsTRTSTSS	phosphorylation down-regulates	19864419	SIGNOR-188893
MKNK1	EIF4E	Ser209	DTATKSGsTTKNRFV	phosphorylation up-regulates	17724079	SIGNOR-157533
MKNK1	EIF4E	–		phosphorylation up-regulates	20626350	SIGNOR-166646
MKNK1	EIF4E	–		phosphorylation up-regulates	9878069	SIGNOR-62936
MKNK1	PLA2G4A	Ser727	RQNPSRCsVSLSNVE	phosphorylation up-regulates activity	10978317	SIGNOR-226633
MKNK1	PNPLA8	Ser511	ELYRKLGsDVFSQNV	phosphorylation up-regulates activity	23258543	SIGNOR-273677

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MKNK1	phosphorylation up-regulates →	SPRY2 PSer112	phosphorylation down-regulates ⊣	SPRY2	19864419	SIGNOR-188889
MKNK1	phosphorylation up-regulates →	SPRY2 PSer121	phosphorylation down-regulates ⊣	SPRY2	19864419	SIGNOR-188893
MKNK1	phosphorylation up-regulates →	EIF4E PSer209	phosphorylation up-regulates →	EIF4E	17724079	SIGNOR-157533
MKNK1	phosphorylation up-regulates →	PLA2G4A PSer727	phosphorylation up-regulates →	PLA2G4A	10978317	SIGNOR-226633
MKNK1	phosphorylation up-regulates →	PNPLA8 PSer511	phosphorylation up-regulates →	PNPLA8	23258543	SIGNOR-273677

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MKNK1	phosphorylation down-regulates	SPRY2	SIGNOR-188889
MKNK1	phosphorylation down-regulates	SPRY2	SIGNOR-188893
MKNK1	phosphorylation → up-regulates	EIF4E	SIGNOR-157533
MKNK1	phosphorylation → up-regulates	EIF4E	SIGNOR-166646
MKNK1	phosphorylation → up-regulates	EIF4E	SIGNOR-62936
MKNK1	phosphorylation → up-regulates activity	PLA2G4A	SIGNOR-226633
MKNK1	phosphorylation → up-regulates activity	PNPLA8	SIGNOR-273677