Summary

Name MKNK1
Full Name MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms MAP kinase signal-integrating kinase 1, MAPK signal-integrating kinase 1, Mnk1 | MNK1
Primary ID Q9BUB5
Links - -
Type protein
Relations 19
Pathways PI3K/AKT
Function May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation SPRY2 0.49
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation EIF4E 0.84
Publications: 3 Organism: Homo Sapiens
Pathways:PI3K/AKT
+ down-regulates activity img/direct_inhibition.png phosphorylation MKNK1 0.68
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PLA2G4A 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation MKNK1 0.48
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1 0.22
Publications: 2 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1
Publications: 3 Organism: Homo Sapiens, In Vitro
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.19
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation MKNK1
Publications: 1 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation MKNK1 0.10
Publications: 1 Organism: Homo Sapiens