Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
Gbeta	MKNK1	–		phosphorylation up-regulates	9155018	SIGNOR-270022
MAPK14	MKNK1	–		phosphorylation up-regulates activity	9155018	SIGNOR-253011
SGK1	MKNK1	Ser353	S-->K	phosphorylation down-regulates activity	28545025	SIGNOR-277357
MAPK3	MKNK1	Thr385 View in OncoXplorer	APEKGLPtPQVLQRN	phosphorylation up-regulates	9155018	SIGNOR-48360
ERK1/2	MKNK1	Thr255	ITTPELTtPCGSAEY	phosphorylation up-regulates activity	17130135	SIGNOR-253015
MAPK1	MKNK1	–		phosphorylation up-regulates	9155017	SIGNOR-48298
MAPK3	MKNK1	–		phosphorylation up-regulates	9155017	SIGNOR-48352
PAK2	MKNK1	Ser39 View in OncoXplorer	RRGRATDsLPGKFED	phosphorylation down-regulates activity	15234964	SIGNOR-250221
MAPK14	MKNK1	Thr250	NSCTPITtPELTTPC	phosphorylation up-regulates activity	9155017	SIGNOR-48342
PPP2CA	MKNK1	Thr250	NSCTPITtPELTTPC	dephosphorylation down-regulates	20927323	SIGNOR-168310
ERK1/2	MKNK1	Thr250	NSCTPITtPELTTPC	phosphorylation up-regulates activity	17130135	SIGNOR-253014
SGK1	MKNK1	Ser352	SEAKDLIsKLLVRDA	phosphorylation down-regulates activity	28545025	SIGNOR-277357
MAPK3	MKNK1	–		phosphorylation up-regulates activity	9155018	SIGNOR-253012
MAPK14	MKNK1	Thr255	ITTPELTtPCGSAEY	phosphorylation up-regulates	9155017	SIGNOR-48346
PPP2CA	MKNK1	Thr255	ITTPELTtPCGSAEY	dephosphorylation down-regulates	20927323	SIGNOR-168314
ERK1/2	MKNK1	–		phosphorylation up-regulates activity	9155018	SIGNOR-253013

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
SGK1	phosphorylation up-regulates →	MKNK1 PSer353	phosphorylation down-regulates ⊣	MKNK1	28545025	SIGNOR-277357
MAPK3	phosphorylation up-regulates →	MKNK1 PThr385	phosphorylation up-regulates →	MKNK1	9155018	SIGNOR-48360
ERK1/2	phosphorylation up-regulates →	MKNK1 PThr255	phosphorylation up-regulates →	MKNK1	17130135	SIGNOR-253015
PAK2	phosphorylation up-regulates →	MKNK1 PSer39	phosphorylation down-regulates ⊣	MKNK1	15234964	SIGNOR-250221
MAPK14	phosphorylation up-regulates →	MKNK1 PThr250	phosphorylation up-regulates →	MKNK1	9155017	SIGNOR-48342
PPP2CA	dephosphorylation down-regulates ⊣	MKNK1 PThr250	dephosphorylation up-regulates →	MKNK1	20927323	SIGNOR-168310
ERK1/2	phosphorylation up-regulates →	MKNK1 PThr250	phosphorylation up-regulates →	MKNK1	17130135	SIGNOR-253014
SGK1	phosphorylation up-regulates →	MKNK1 PSer352	phosphorylation down-regulates ⊣	MKNK1	28545025	SIGNOR-277357
MAPK14	phosphorylation up-regulates →	MKNK1 PThr255	phosphorylation up-regulates →	MKNK1	9155017	SIGNOR-48346
PPP2CA	dephosphorylation down-regulates ⊣	MKNK1 PThr255	dephosphorylation up-regulates →	MKNK1	20927323	SIGNOR-168314

Regulator	Mechanism/Effect	Target	SIGNOR-ID
Gbeta	phosphorylation → up-regulates	MKNK1	SIGNOR-270022
MAPK14	phosphorylation → up-regulates activity	MKNK1	SIGNOR-253011
SGK1	phosphorylation → down-regulates activity	MKNK1	SIGNOR-277357
MAPK3	phosphorylation → up-regulates	MKNK1	SIGNOR-48360
ERK1/2	phosphorylation → up-regulates activity	MKNK1	SIGNOR-253015
MAPK1	phosphorylation → up-regulates	MKNK1	SIGNOR-48298
MAPK3	phosphorylation → up-regulates	MKNK1	SIGNOR-48352
PAK2	phosphorylation → down-regulates activity	MKNK1	SIGNOR-250221
MAPK14	phosphorylation → up-regulates activity	MKNK1	SIGNOR-48342
PPP2CA	dephosphorylation down-regulates	MKNK1	SIGNOR-168310
ERK1/2	phosphorylation → up-regulates activity	MKNK1	SIGNOR-253014
SGK1	phosphorylation → down-regulates activity	MKNK1	SIGNOR-277357
MAPK3	phosphorylation → up-regulates activity	MKNK1	SIGNOR-253012
MAPK14	phosphorylation → up-regulates	MKNK1	SIGNOR-48346
PPP2CA	dephosphorylation down-regulates	MKNK1	SIGNOR-168314
ERK1/2	phosphorylation → up-regulates activity	MKNK1	SIGNOR-253013