Entity Details

Name PPP2CA_Thr250
ID Q9BUB5
Role residue
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
ERK1/2MKNK1Thr250NSCTPITtPELTTPCphosphorylation
up-regulates activity		17130135SIGNOR-253014
MAPK14MKNK1Thr250NSCTPITtPELTTPCphosphorylation
up-regulates activity		9155017SIGNOR-48342
PPP2CAMKNK1Thr250NSCTPITtPELTTPCdephosphorylation
down-regulates		20927323SIGNOR-168310
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
ERK1/2phosphorylation
up-regulates
→
MKNK1
PThr250		phosphorylation
up-regulates
→		MKNK117130135SIGNOR-253014
MAPK14phosphorylation
up-regulates
→
MKNK1
PThr250		phosphorylation
up-regulates
→		MKNK19155017SIGNOR-48342
PPP2CAdephosphorylation
down-regulates
⊣
MKNK1
PThr250		dephosphorylation
up-regulates
→		MKNK120927323SIGNOR-168310
Regulator Mechanism/Effect Target SIGNOR-ID
ERK1/2phosphorylation
→
up-regulates activity 		MKNK1SIGNOR-253014
MAPK14phosphorylation
→
up-regulates activity 		MKNK1SIGNOR-48342
PPP2CAdephosphorylation
img/direct_inhibition.png
down-regulates 		MKNK1SIGNOR-168310