| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | MKNK1 | Thr255 | ITTPELTtPCGSAEY | phosphorylation up-regulates | 9155017 | SIGNOR-48346 |
| PPP2CA | MKNK1 | Thr255 | ITTPELTtPCGSAEY | dephosphorylation down-regulates | 20927323 | SIGNOR-168314 |
| ERK1/2 | MKNK1 | Thr255 | ITTPELTtPCGSAEY | phosphorylation up-regulates activity | 17130135 | SIGNOR-253015 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | MKNK1 PThr255 | phosphorylation up-regulates → | MKNK1 | 9155017 | SIGNOR-48346 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MKNK1 PThr255 | dephosphorylation up-regulates → | MKNK1 | 20927323 | SIGNOR-168314 |
| ERK1/2 | phosphorylation up-regulates → | MKNK1 PThr255 | phosphorylation up-regulates → | MKNK1 | 17130135 | SIGNOR-253015 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation → up-regulates | MKNK1 | SIGNOR-48346 |
| PPP2CA | dephosphorylation down-regulates | MKNK1 | SIGNOR-168314 |
| ERK1/2 | phosphorylation → up-regulates activity | MKNK1 | SIGNOR-253015 |
