| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | NDEL1 | Thr219 | ASLSLPAtPVGKGTE | phosphorylation up-regulates activity | 12796778 | SIGNOR-250678 |
| MAPK1 | NDEL1 | Thr219 | ASLSLPAtPVGKGTE | phosphorylation up-regulates activity | 12556484 | SIGNOR-274076 |
| CDK1 | NDEL1 | Ser242 | IPNGFGTsPLTPSAR | phosphorylation up-regulates activity | 12556484 | SIGNOR-274073 |
| MAPK1 | NDEL1 | Thr245 | GFGTSPLtPSARISA | phosphorylation up-regulates activity | 12556484 | SIGNOR-274075 |
| CDK5 | NDEL1 | Ser242 | IPNGFGTsPLTPSAR | phosphorylation up-regulates activity | 12796778 | SIGNOR-250677 |
| CyclinD1/CDK6 | NDEL1 | Thr245 | GFGTSPLtPSARISA | phosphorylation up-regulates activity | 12796778 | SIGNOR-250652 |
| CDK1 | NDEL1 | Thr245 | GFGTSPLtPSARISA | phosphorylation up-regulates activity | 12556484 | SIGNOR-274072 |
| CDK1 | NDEL1 | Thr219 | ASLSLPAtPVGKGTE | phosphorylation up-regulates activity | 12556484 | SIGNOR-274074 |
| AURKA | NDEL1 | Ser251 | LTPSARIsALNIVGD | phosphorylation down-regulates quantity by destabilization | 17060449 | SIGNOR-263159 |
| PPP4C | NDEL1 | Thr219 | ASLSLPAtPVGKGTE | dephosphorylation down-regulates activity | 18347064 | SIGNOR-248550 |
| CDK5 | NDEL1 | Ser231 | GTENTFPsPKAIPNG | phosphorylation up-regulates activity | 12796778 | SIGNOR-250676 |
| CDK5 | NDEL1 | Ser198 | TRKSAPSsPTLDCEK | phosphorylation up-regulates activity | 12796778 | SIGNOR-250675 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation up-regulates → | NDEL1 PThr219 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250678 |
| MAPK1 | phosphorylation up-regulates → | NDEL1 PThr219 | phosphorylation up-regulates → | NDEL1 | 12556484 | SIGNOR-274076 |
| CDK1 | phosphorylation up-regulates → | NDEL1 PSer242 | phosphorylation up-regulates → | NDEL1 | 12556484 | SIGNOR-274073 |
| MAPK1 | phosphorylation up-regulates → | NDEL1 PThr245 | phosphorylation up-regulates → | NDEL1 | 12556484 | SIGNOR-274075 |
| CDK5 | phosphorylation up-regulates → | NDEL1 PSer242 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250677 |
| CyclinD1/CDK6 | phosphorylation up-regulates → | NDEL1 PThr245 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250652 |
| CDK1 | phosphorylation up-regulates → | NDEL1 PThr245 | phosphorylation up-regulates → | NDEL1 | 12556484 | SIGNOR-274072 |
| CDK1 | phosphorylation up-regulates → | NDEL1 PThr219 | phosphorylation up-regulates → | NDEL1 | 12556484 | SIGNOR-274074 |
| AURKA | phosphorylation up-regulates → | NDEL1 PSer251 | phosphorylation down-regulates ⊣ | NDEL1 | 17060449 | SIGNOR-263159 |
| PPP4C | dephosphorylation down-regulates ⊣ | NDEL1 PThr219 | dephosphorylation up-regulates → | NDEL1 | 18347064 | SIGNOR-248550 |
| CDK5 | phosphorylation up-regulates → | NDEL1 PSer231 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250676 |
| CDK5 | phosphorylation up-regulates → | NDEL1 PSer198 | phosphorylation up-regulates → | NDEL1 | 12796778 | SIGNOR-250675 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK5/CDK5R1 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250678 |
| MAPK1 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-274076 |
| CDK1 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-274073 |
| MAPK1 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-274075 |
| CDK5 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250677 |
| CyclinD1/CDK6 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250652 |
| CDK1 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-274072 |
| CDK1 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-274074 |
| AURKA | phosphorylation down-regulates quantity by destabilization | NDEL1 | SIGNOR-263159 |
| PPP4C | dephosphorylation → down-regulates activity | NDEL1 | SIGNOR-248550 |
| CDK5 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250676 |
| CDK5 | phosphorylation → up-regulates activity | NDEL1 | SIGNOR-250675 |
