Summary

Name NDEL1
Full Name Nuclear distribution protein nudE-like 1
Synonyms Protein Nudel, Mitosin-associated protein 1 | EOPA, MITAP1, NUDEL
Primary ID Q9GZM8
Links - -
Type protein
Relations 16
Function Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation NDEL1 0.765
Publications: 3 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NDEL1 0.645
Publications: 3 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NDEL1 0.587
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation NDEL1 0.411
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NDEL1 0.622
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation NDEL1 0.294
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation NDEL1 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding DYNC1H1 0.707
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding NDEL1 0.65
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NDEL1 0.606
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NDEL1 0.839
Publications: 1 Organism: Mus Musculus