Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
SIK2	LRP6	Ser1490	AILNPPPsPATERSH	phosphorylation up-regulates activity	35277657	SIGNOR-275404
SIK2	LRP6	Ser1490	AILNPPPsPATERSH	phosphorylation up-regulates activity	35277657	SIGNOR-275399
SIK2	PIK3R1	Ser154	STLYRTQsSSNLAEL	phosphorylation up-regulates activity	27478041	SIGNOR-277269
SIK2	IRS1	Ser794	QHLRLSTsSGRLLYA	phosphorylation down-regulates quantity	24841198	SIGNOR-265745
SIK2	IRS1	Ser794	QHLRLSTsSGRLLYA	phosphorylation unknown	12624099	SIGNOR-99055
SIK2	IRS1	Ser794	QHLRLSTsSGRLLYA	phosphorylation unknown	12624099	SIGNOR-99059
SIK2	EP300	Ser89	SELLRSGsSPNLNMG	phosphorylation down-regulates activity	26983400	SIGNOR-278368
SIK2	CDK5R1	Ser91	ENLKKSLsCANLSTF	phosphorylation down-regulates	24561619	SIGNOR-204648
SIK2	CRTC2	Ser171	SALNRTSsDSALHTS	phosphorylation down-regulates	16308421	SIGNOR-142218
SIK2	CRTC2	Ser171	SALNRTSsDSALHTS	phosphorylation down-regulates	20577053	SIGNOR-166372
SIK2	CEP250	Ser2392	AGLHHSLsHSLLAVA	phosphorylation down-regulates	20708153	SIGNOR-167488
SIK2	CEP250	Ser2394	LHHSLSHsLLAVAQA	phosphorylation unknown	20708153	SIGNOR-167492
SIK2	SIK2	Ser343 View in OncoXplorer	RLKSHRSsFPVEQRL	phosphorylation up-regulates activity	27478041	SIGNOR-277268

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
SIK2	phosphorylation up-regulates →	LRP6 PSer1490	phosphorylation up-regulates →	LRP6	35277657	SIGNOR-275404
SIK2	phosphorylation up-regulates →	LRP6 PSer1490	phosphorylation up-regulates →	LRP6	35277657	SIGNOR-275399
SIK2	phosphorylation up-regulates →	PIK3R1 PSer154	phosphorylation up-regulates →	PIK3R1	27478041	SIGNOR-277269
SIK2	phosphorylation up-regulates →	IRS1 PSer794	phosphorylation down-regulates ⊣	IRS1	24841198	SIGNOR-265745
SIK2	phosphorylation up-regulates →	IRS1 PSer794	phosphorylation down-regulates ⊣	IRS1	12624099	SIGNOR-99055
SIK2	phosphorylation up-regulates →	IRS1 PSer794	phosphorylation down-regulates ⊣	IRS1	12624099	SIGNOR-99059
SIK2	phosphorylation up-regulates →	EP300 PSer89	phosphorylation down-regulates ⊣	EP300	26983400	SIGNOR-278368
SIK2	phosphorylation up-regulates →	CDK5R1 PSer91	phosphorylation down-regulates ⊣	CDK5R1	24561619	SIGNOR-204648
SIK2	phosphorylation up-regulates →	CRTC2 PSer171	phosphorylation down-regulates ⊣	CRTC2	16308421	SIGNOR-142218
SIK2	phosphorylation up-regulates →	CRTC2 PSer171	phosphorylation down-regulates ⊣	CRTC2	20577053	SIGNOR-166372
SIK2	phosphorylation up-regulates →	CEP250 PSer2392	phosphorylation down-regulates ⊣	CEP250	20708153	SIGNOR-167488
SIK2	phosphorylation up-regulates →	CEP250 PSer2394	phosphorylation down-regulates ⊣	CEP250	20708153	SIGNOR-167492
SIK2	phosphorylation up-regulates →	SIK2 PSer343	phosphorylation up-regulates →	SIK2	27478041	SIGNOR-277268

Regulator	Mechanism/Effect	Target	SIGNOR-ID
SIK2	phosphorylation → up-regulates activity	LRP6	SIGNOR-275404
SIK2	phosphorylation → up-regulates activity	LRP6	SIGNOR-275399
SIK2	phosphorylation → up-regulates activity	PIK3R1	SIGNOR-277269
SIK2	phosphorylation → down-regulates quantity	IRS1	SIGNOR-265745
SIK2	phosphorylation → unknown	IRS1	SIGNOR-99055
SIK2	phosphorylation → unknown	IRS1	SIGNOR-99059
SIK2	phosphorylation → down-regulates activity	EP300	SIGNOR-278368
SIK2	phosphorylation down-regulates	CDK5R1	SIGNOR-204648
SIK2	phosphorylation down-regulates	CRTC2	SIGNOR-142218
SIK2	phosphorylation down-regulates	CRTC2	SIGNOR-166372
SIK2	phosphorylation down-regulates	CEP250	SIGNOR-167488
SIK2	phosphorylation → unknown	CEP250	SIGNOR-167492
SIK2	phosphorylation → up-regulates activity	SIK2	SIGNOR-277268