| + |
SIK2 | up-regulates activity 
phosphorylation
|
LRP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275404 |
Ser1490 |
AILNPPPsPATERSH |
Homo sapiens |
Breast Cancer Stem Cell |
| pmid |
sentence |
| 35277657 |
Mechanistically, SIK2, phosphorylated by CK1α, directly phosphorylated LRP6 in a SIK2 kinase activity-dependent manner, leading to Wnt/β-catenin signaling pathway activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275399 |
Ser1490 |
AILNPPPsPATERSH |
Homo sapiens |
Breast Cancer Stem Cell |
| pmid |
sentence |
| 35277657 |
Mechanistically, SIK2, phosphorylated by CK1α, directly phosphorylated LRP6 in a SIK2 kinase activity-dependent manner, leading to Wnt/β-catenin signaling pathway activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIK2 | up-regulates activity
phosphorylation
|
PIK3R1 |
0.315 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277269 |
Ser154 |
STLYRTQsSSNLAEL |
in vitro |
|
| pmid |
sentence |
| 27478041 |
The Regulatory Subunit of PI3K Is a Direct Catalytic Target of SIK2. These data confirm that p85α is a direct catalytic substrate of SIK2 and that SIK2 S154 phosphorylation significantly increases the activity of the PI3K/AKT pathway in ovarian cancer cells. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SIK2 | down-regulates 
phosphorylation
|
CRTC2 |
0.756 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142218 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166372 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIK2 | down-regulates
phosphorylation
|
CEP250 |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167488 |
Ser2392 |
AGLHHSLsHSLLAVA |
Homo sapiens |
|
| pmid |
sentence |
| 20708153 |
Here, we show that the salt inducible kinase 2 (sik2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, c-nap1, through s2392 phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIK2 |
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4.0
SIK2
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