| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | NHEJ1 | Ser245 | PHTSNSAsLQGIDSQ | phosphorylation unknown | 18644470 | SIGNOR-179532 |
| ATM | NHEJ1 | Ser251 | ASLQGIDsQCVNQPE | phosphorylation unknown | 18644470 | SIGNOR-179528 |
| AKT1 | NHEJ1 | Thr181 | LIRDRLKtEPFEENS | phosphorylation down-regulates quantity by destabilization | 25661488 | SIGNOR-276881 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKDC | phosphorylation up-regulates → | NHEJ1 PSer245 | phosphorylation down-regulates ⊣ | NHEJ1 | 18644470 | SIGNOR-179532 |
| ATM | phosphorylation up-regulates → | NHEJ1 PSer251 | phosphorylation down-regulates ⊣ | NHEJ1 | 18644470 | SIGNOR-179528 |
| AKT1 | phosphorylation up-regulates → | NHEJ1 PThr181 | phosphorylation down-regulates ⊣ | NHEJ1 | 25661488 | SIGNOR-276881 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKDC | phosphorylation → unknown | NHEJ1 | SIGNOR-179532 |
| ATM | phosphorylation → unknown | NHEJ1 | SIGNOR-179528 |
| AKT1 | phosphorylation down-regulates quantity by destabilization | NHEJ1 | SIGNOR-276881 |
