Entity Details

Name AKT1_Thr181
ID Q9H9Q4
Role residue
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Data Summary
PTM Format
SIGNOR Summary

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Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SCF-betaTRCPNHEJ1Thr181LIRDRLKtEPFEENSubiquitination
down-regulates quantity by destabilization		25661488SIGNOR-276882
AKT1NHEJ1Thr181LIRDRLKtEPFEENSphosphorylation
down-regulates quantity by destabilization		25661488SIGNOR-276881
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SCF-betaTRCPubiquitination

⊣
NHEJ1
PThr181		ubiquitination

⊣		NHEJ125661488SIGNOR-276882
AKT1phosphorylation
up-regulates
→
NHEJ1
PThr181		phosphorylation
down-regulates
⊣		NHEJ125661488SIGNOR-276881
Regulator Mechanism/Effect Target SIGNOR-ID
SCF-betaTRCPubiquitination
img/direct_inhibition.png
down-regulates quantity by destabilization 		NHEJ1SIGNOR-276882
AKT1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		NHEJ1SIGNOR-276881