Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CLK4	MITF	Tyr360	ILKASVDyIRKLQRE	phosphorylation down-regulates quantity by destabilization	35092699	SIGNOR-274116
CLK4	ABL1	Thr735	DTEWRSVtLPRDLQS	phosphorylation down-regulates	18794806	SIGNOR-181052
CLK4	SRSF1	–		phosphorylation up-regulates activity	8617202	SIGNOR-273860
CLK4	NR5A1	Ser203	EYPEPYAsPPQPGLP	phosphorylation up-regulates activity	35592512	SIGNOR-274117

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CLK4	phosphorylation up-regulates →	MITF PTyr360	phosphorylation down-regulates ⊣	MITF	35092699	SIGNOR-274116
CLK4	phosphorylation up-regulates →	ABL1 PThr735	phosphorylation down-regulates ⊣	ABL1	18794806	SIGNOR-181052
CLK4	phosphorylation up-regulates →	NR5A1 PSer203	phosphorylation up-regulates →	NR5A1	35592512	SIGNOR-274117

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CLK4	phosphorylation down-regulates quantity by destabilization	MITF	SIGNOR-274116
CLK4	phosphorylation down-regulates	ABL1	SIGNOR-181052
CLK4	phosphorylation → up-regulates activity	SRSF1	SIGNOR-273860
CLK4	phosphorylation → up-regulates activity	NR5A1	SIGNOR-274117