| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKC | TRPV4 | Ser162 | FDIVSRGsTADLDGL | phosphorylation up-regulates activity | 19661060 | SIGNOR-276229 |
| SGK1 | TRPV4 | Ser824 | LRRDRWSsVVPRVVE | phosphorylation up-regulates activity | 25972993 | SIGNOR-279386 |
| PRKCA | TRPV4 | Ser189 | DEEFREPsTGKTCLP | phosphorylation up-regulates activity | 19661060 | SIGNOR-260884 |
| PRKCA | TRPV4 | Ser162 | FDIVSRGsTADLDGL | phosphorylation up-regulates activity | 19661060 | SIGNOR-260886 |
| PKC | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-276228 |
| PKA | TRPV4 | Ser162 | FDIVSRGsTADLDGL | phosphorylation up-regulates activity | 19661060 | SIGNOR-260885 |
| PKA | TRPV4 | Ser189 | DEEFREPsTGKTCLP | phosphorylation up-regulates activity | 19661060 | SIGNOR-276233 |
| PRKCA | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-260882 |
| PKA | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-276231 |
| PKA | TRPV4 | Ser189 | DEEFREPsTGKTCLP | phosphorylation up-regulates activity | 19661060 | SIGNOR-260883 |
| PKA | TRPV4 | Ser162 | FDIVSRGsTADLDGL | phosphorylation up-regulates activity | 19661060 | SIGNOR-276232 |
| PKC | TRPV4 | Ser189 | DEEFREPsTGKTCLP | phosphorylation up-regulates activity | 19661060 | SIGNOR-276230 |
| FYN | TRPV4 | – | phosphorylation up-regulates activity | 34575985 | SIGNOR-279991 | |
| PKA | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-260881 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKC | phosphorylation up-regulates → | TRPV4 PSer162 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276229 |
| SGK1 | phosphorylation up-regulates → | TRPV4 PSer824 | phosphorylation up-regulates → | TRPV4 | 25972993 | SIGNOR-279386 |
| PRKCA | phosphorylation up-regulates → | TRPV4 PSer189 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-260884 |
| PRKCA | phosphorylation up-regulates → | TRPV4 PSer162 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-260886 |
| PKC | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276228 |
| PKA | phosphorylation up-regulates → | TRPV4 PSer162 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-260885 |
| PKA | phosphorylation up-regulates → | TRPV4 PSer189 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276233 |
| PRKCA | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-260882 |
| PKA | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276231 |
| PKA | phosphorylation up-regulates → | TRPV4 PSer189 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-260883 |
| PKA | phosphorylation up-regulates → | TRPV4 PSer162 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276232 |
| PKC | phosphorylation up-regulates → | TRPV4 PSer189 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276230 |
| PKA | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-260881 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKC | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276229 |
| SGK1 | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-279386 |
| PRKCA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-260884 |
| PRKCA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-260886 |
| PKC | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276228 |
| PKA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-260885 |
| PKA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276233 |
| PRKCA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-260882 |
| PKA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276231 |
| PKA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-260883 |
| PKA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276232 |
| PKC | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276230 |
| FYN | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-279991 |
| PKA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-260881 |
