Summary

Name TRPV4
Full Name Transient receptor potential cation channel subfamily V member 4
Synonyms TrpV4, Osm-9-like TRP channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, VRL-2, Vanilloid receptor-related osmotically-activated channel, VR-OAC | VRL2, VROAC
Primary ID Q9HBA0
Links - -
Type protein
Relations 17
Function Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040, PubMed:29899501). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260). In its inactive state, may sequester DDX3X at the plasma membrane. When activated, the interaction between both proteins is affected and DDX3X relocalizes to the nucleus (PubMed:29899501).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PKAup-regulates activity img/direct-activation.png phosphorylation TRPV4 0.2
Publications: 6 Organism: In Vitro, Homo Sapiens
+ PKCup-regulates activity img/direct-activation.png phosphorylation TRPV4 0.2
Publications: 3 Organism: In Vitro
+ PRKCAup-regulates activity img/direct-activation.png phosphorylation TRPV4 0.352
Publications: 3 Organism: Homo Sapiens
+ GSK1016790Aup-regulates activity img/direct-activation.png binding TRPV4 0.8
Publications: 1
+ ITCHdown-regulates activity img/direct_inhibition.png ubiquitination TRPV4 0.386
Publications: 1 Organism: Homo Sapiens
+ TRPV4down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation UCP1 0.293
Publications: 1 Organism: Mus Musculus
+ TRPV4down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PPARGC1A 0.2
Publications: 1 Organism: Mus Musculus
+ OS9up-regulates quantity by stabilization img/direct-activation.png binding TRPV4 0.383
Publications: 1 Organism: Homo Sapiens