| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-260881 |
| PRKCA | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-260882 |
| PKA | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-276231 |
| PKC | TRPV4 | Thr175 | GLLPFLLtHKKRLTD | phosphorylation up-regulates activity | 19661060 | SIGNOR-276228 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-260881 |
| PRKCA | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-260882 |
| PKA | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276231 |
| PKC | phosphorylation up-regulates → | TRPV4 PThr175 | phosphorylation up-regulates → | TRPV4 | 19661060 | SIGNOR-276228 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-260881 |
| PRKCA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-260882 |
| PKA | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276231 |
| PKC | phosphorylation → up-regulates activity | TRPV4 | SIGNOR-276228 |