Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
PAK6	SYNJ1	–		phosphorylation up-regulates activity	22371566	SIGNOR-263022
PAK6	AIFM1	Thr281	GAEVKSRtTLFRKIG	phosphorylation down-regulates activity	33867848	SIGNOR-278969
PAK6	RAF1	Ser338	RPRGQRDsSYYWEIE	phosphorylation up-regulates activity	18465753	SIGNOR-278971
PAK6	SLC25A5	Thr107	LGGVDKRtQFWLYFA	phosphorylation up-regulates quantity	32194820	SIGNOR-279473
PAK6	RHOC	–		phosphorylation down-regulates activity	28486133	SIGNOR-280059
PAK6	AR	Ser579	YGALTCGsCKVFFKR	phosphorylation down-regulates quantity by destabilization	23132866	SIGNOR-279247
PAK6	GATA1	Ser161	SSLPVPNsAYGGPDF	phosphorylation up-regulates activity	25726523	SIGNOR-278416
PAK6	GATA1	Ser187	LNSAAYSsPKLRGTL	phosphorylation up-regulates activity	25726523	SIGNOR-278415
PAK6	CTNNB1	–		phosphorylation down-regulates quantity	24352566	SIGNOR-279546
PAK6	SOX2	–		phosphorylation up-regulates quantity	32721391	SIGNOR-280060
PAK6	LIMK1	Thr508	PDRKKRYtVVGNPYW	phosphorylation up-regulates activity	25714010	SIGNOR-278970
PAK6	MDM2	Ser186	RQRKRHKsDSISLSF	phosphorylation up-regulates activity	23132866	SIGNOR-276427
PAK6	MDM2	Thr158	HLVSRPStSSRRRAI	phosphorylation up-regulates activity	23132866	SIGNOR-276428
PAK6	PACSIN1	Ser346	SQAGDRGsVSSYDRG	phosphorylation up-regulates activity	22371566	SIGNOR-263021

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
PAK6	phosphorylation up-regulates →	AIFM1 PThr281	phosphorylation down-regulates ⊣	AIFM1	33867848	SIGNOR-278969
PAK6	phosphorylation up-regulates →	RAF1 PSer338	phosphorylation up-regulates →	RAF1	18465753	SIGNOR-278971
PAK6	phosphorylation up-regulates →	SLC25A5 PThr107	phosphorylation up-regulates →	SLC25A5	32194820	SIGNOR-279473
PAK6	phosphorylation up-regulates →	AR PSer579	phosphorylation down-regulates ⊣	AR	23132866	SIGNOR-279247
PAK6	phosphorylation up-regulates →	GATA1 PSer161	phosphorylation up-regulates →	GATA1	25726523	SIGNOR-278416
PAK6	phosphorylation up-regulates →	GATA1 PSer187	phosphorylation up-regulates →	GATA1	25726523	SIGNOR-278415
PAK6	phosphorylation up-regulates →	LIMK1 PThr508	phosphorylation up-regulates →	LIMK1	25714010	SIGNOR-278970
PAK6	phosphorylation up-regulates →	MDM2 PSer186	phosphorylation up-regulates →	MDM2	23132866	SIGNOR-276427
PAK6	phosphorylation up-regulates →	MDM2 PThr158	phosphorylation up-regulates →	MDM2	23132866	SIGNOR-276428
PAK6	phosphorylation up-regulates →	PACSIN1 PSer346	phosphorylation up-regulates →	PACSIN1	22371566	SIGNOR-263021

Regulator	Mechanism/Effect	Target	SIGNOR-ID
PAK6	phosphorylation → up-regulates activity	SYNJ1	SIGNOR-263022
PAK6	phosphorylation → down-regulates activity	AIFM1	SIGNOR-278969
PAK6	phosphorylation → up-regulates activity	RAF1	SIGNOR-278971
PAK6	phosphorylation → up-regulates quantity	SLC25A5	SIGNOR-279473
PAK6	phosphorylation → down-regulates activity	RHOC	SIGNOR-280059
PAK6	phosphorylation down-regulates quantity by destabilization	AR	SIGNOR-279247
PAK6	phosphorylation → up-regulates activity	GATA1	SIGNOR-278416
PAK6	phosphorylation → up-regulates activity	GATA1	SIGNOR-278415
PAK6	phosphorylation → down-regulates quantity	CTNNB1	SIGNOR-279546
PAK6	phosphorylation → up-regulates quantity	SOX2	SIGNOR-280060
PAK6	phosphorylation → up-regulates activity	LIMK1	SIGNOR-278970
PAK6	phosphorylation → up-regulates activity	MDM2	SIGNOR-276427
PAK6	phosphorylation → up-regulates activity	MDM2	SIGNOR-276428
PAK6	phosphorylation → up-regulates activity	PACSIN1	SIGNOR-263021