Name PAK6
Full Name Serine/threonine-protein kinase PAK 6
Synonyms PAK-5, p21-activated kinase 6, PAK-6 | PAK5
Primary ID Q9NQU5
Links - -
Type protein
Relations 2
Function Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.


Modifications Tables


Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PAK6 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PAK6 0.28
Publications: 1 Organism: Homo Sapiens