Entity Details

Name DROSHA
ID Q9NRR4
Role substrate
Enzymatic Domains
RNase III 1 876-1056
RNase III 2 1107-1233
DRBM 1260-1334
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BDROSHASer300
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RHRDNRRsPSLERSYphosphorylation
up-regulates activity		25699712SIGNOR-264845
p38DROSHASer300
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RHRDNRRsPSLERSYphosphorylation
down-regulates activity		25699712SIGNOR-264847
GSK3BDROSHASer302RDNRRSPsLERSYKKphosphorylation
up-regulates activity		25699712SIGNOR-264846
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
DROSHA
PSer300		phosphorylation
up-regulates
→		DROSHA25699712SIGNOR-264845
p38phosphorylation
up-regulates
→
DROSHA
PSer300		phosphorylation
down-regulates
⊣		DROSHA25699712SIGNOR-264847
GSK3Bphosphorylation
up-regulates
→
DROSHA
PSer302		phosphorylation
up-regulates
→		DROSHA25699712SIGNOR-264846
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
→
up-regulates activity 		DROSHASIGNOR-264845
p38phosphorylation
→
down-regulates activity 		DROSHASIGNOR-264847
GSK3Bphosphorylation
→
up-regulates activity 		DROSHASIGNOR-264846