Summary

Name DROSHA
Full Name Ribonuclease 3
Synonyms Protein Drosha, Ribonuclease III, RNase III, p241 | RN3, RNASE3L, RNASEN
Primary ID Q9NRR4
Links - -
Type protein
Relations 4
Function Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation DROSHA 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DROSHA 0.281
Publications: 2 Organism: In Vitro
+ form complex img/form-complex.png binding Microprocessor complex 0.921
Publications: 1 Organism: Homo Sapiens