| Name | RASSF1 |
| ID | Q9NS23 |
| Role | substrate |
| Enzymatic Domains |
Ras-associating 198-292 PROSITE-ProRule
SARAH 294-341 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | RASSF1 | Ser188 | PSSKKPPsLQDARRG | phosphorylation unknown | 24197116 | SIGNOR-203144 |
| AURKA | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 17563743 | SIGNOR-155815 |
| ATM | RASSF1 | Ser135 | EWETPDLsQAEIEQK | phosphorylation up-regulates | 19962312 | SIGNOR-161934 |
| AURKB | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 19276349 | SIGNOR-184561 |
| CyclinD/CDK4 | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 18071316 | SIGNOR-216976 |
| CDK4 | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 18071316 | SIGNOR-159849 |
| AURKA | RASSF1 | Thr206 | GTSVRRRtSFYLPKD | phosphorylation down-regulates | 17563743 | SIGNOR-155819 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | RASSF1 PSer188 | phosphorylation down-regulates ⊣ | RASSF1 | 24197116 | SIGNOR-203144 |
| AURKA | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 17563743 | SIGNOR-155815 |
| ATM | phosphorylation up-regulates → | RASSF1 PSer135 | phosphorylation up-regulates → | RASSF1 | 19962312 | SIGNOR-161934 |
| AURKB | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 19276349 | SIGNOR-184561 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 18071316 | SIGNOR-216976 |
| CDK4 | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 18071316 | SIGNOR-159849 |
| AURKA | phosphorylation up-regulates → | RASSF1 PThr206 | phosphorylation down-regulates ⊣ | RASSF1 | 17563743 | SIGNOR-155819 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → unknown | RASSF1 | SIGNOR-203144 |
| AURKA | phosphorylation down-regulates | RASSF1 | SIGNOR-155815 |
| ATM | phosphorylation → up-regulates | RASSF1 | SIGNOR-161934 |
| AURKB | phosphorylation down-regulates | RASSF1 | SIGNOR-184561 |
| CyclinD/CDK4 | phosphorylation down-regulates | RASSF1 | SIGNOR-216976 |
| CDK4 | phosphorylation down-regulates | RASSF1 | SIGNOR-159849 |
| AURKA | phosphorylation down-regulates | RASSF1 | SIGNOR-155819 |