Summary

Name RASSF1
Full Name Ras association domain-containing protein 1
Synonyms RASF1_HUMAN | RDA32
Primary ID Q9NS23
Links - -
Type protein
Relations 19
Pathways Non-small-cell lung cancer (NSCLC)
Function Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation RASSF1 0.57
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RASSF1 0.364
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RASSF1 0.463
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RASSF1 0.422
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RASSF1 0.491
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation RASSF1 0.454
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STK4 0.799
Publications: 2 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates activity img/direct-activation.png binding STK3 0.682
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates activity img/direct-activation.png binding RASSF1 0.598
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STK3/4 0.799
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates img/direct-activation.png binding STK3 0.682
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates img/direct_inhibition.png binding RASSF1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ up-regulates img/indirect-activation.png RASSF1 0.261
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RASSF1 0.638
Publications: 1 Organism: Homo Sapiens
Pathways:Non-small-cell lung cancer (NSCLC)
+ up-regulates img/direct-activation.png binding RASSF1 0.414
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png post transcriptional regulation CCND1 0.56
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RASSF1 0.521
Publications: 1 Organism: Homo Sapiens