| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 17563743 | SIGNOR-155815 |
| AURKB | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 19276349 | SIGNOR-184561 |
| CyclinD/CDK4 | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 18071316 | SIGNOR-216976 |
| CDK4 | RASSF1 | Ser207 | TSVRRRTsFYLPKDA | phosphorylation down-regulates | 18071316 | SIGNOR-159849 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKA | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 17563743 | SIGNOR-155815 |
| AURKB | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 19276349 | SIGNOR-184561 |
| CyclinD/CDK4 | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 18071316 | SIGNOR-216976 |
| CDK4 | phosphorylation up-regulates → | RASSF1 PSer207 | phosphorylation down-regulates ⊣ | RASSF1 | 18071316 | SIGNOR-159849 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKA | phosphorylation down-regulates | RASSF1 | SIGNOR-155815 |
| AURKB | phosphorylation down-regulates | RASSF1 | SIGNOR-184561 |
| CyclinD/CDK4 | phosphorylation down-regulates | RASSF1 | SIGNOR-216976 |
| CDK4 | phosphorylation down-regulates | RASSF1 | SIGNOR-159849 |
