| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK2 | SPHK1 | Ser225 | VGSKTPAsPVVVQQG | phosphorylation up-regulates activity | 32801355 | SIGNOR-278514 |
| MAPK3 | SPHK1 | Ser225 | VGSKTPAsPVVVQQG | phosphorylation up-regulates | 14532121 | SIGNOR-118550 |
| ERK1/2 | SPHK1 | Ser225 | VGSKTPAsPVVVQQG | phosphorylation up-regulates | 14532121 | SIGNOR-118542 |
| MAPK1 | SPHK1 | Ser225 | VGSKTPAsPVVVQQG | phosphorylation up-regulates | 14532121 | SIGNOR-118546 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK2 | phosphorylation up-regulates → | SPHK1 PSer225 | phosphorylation up-regulates → | SPHK1 | 32801355 | SIGNOR-278514 |
| MAPK3 | phosphorylation up-regulates → | SPHK1 PSer225 | phosphorylation up-regulates → | SPHK1 | 14532121 | SIGNOR-118550 |
| ERK1/2 | phosphorylation up-regulates → | SPHK1 PSer225 | phosphorylation up-regulates → | SPHK1 | 14532121 | SIGNOR-118542 |
| MAPK1 | phosphorylation up-regulates → | SPHK1 PSer225 | phosphorylation up-regulates → | SPHK1 | 14532121 | SIGNOR-118546 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EIF2AK2 | phosphorylation → up-regulates activity | SPHK1 | SIGNOR-278514 |
| MAPK3 | phosphorylation → up-regulates | SPHK1 | SIGNOR-118550 |
| ERK1/2 | phosphorylation → up-regulates | SPHK1 | SIGNOR-118542 |
| MAPK1 | phosphorylation → up-regulates | SPHK1 | SIGNOR-118546 |
