Summary

Name SPHK1
Full Name Sphingosine kinase 1
Synonyms SK 1, SPK 1 | SPHK, SPK
Primary ID Q9NYA1
Links - -
Type protein
Relations 7
Function Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol (PubMed:20577214, PubMed:23602659, PubMed:29662056, PubMed:24929359, PubMed:11923095). In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis (PubMed:16118219). Involved in the regulation of inflammatory response and neuroinflammation. Via the product sphingosine 1-phosphate, stimulates TRAF2 E3 ubiquitin ligase activity, and promotes activation of NF-kappa-B in response to TNF signaling leading to IL17 secretion (PubMed:20577214). In response to TNF and in parallel to NF-kappa-B activation, negatively regulates RANTES induction through p38 MAPK signaling pathway (PubMed:23935096). Involved in endocytic membrane trafficking induced by sphingosine, recruited to dilate endosomes, also plays a role on later stages of endosomal maturation and membrane fusion independently of its kinase activity (PubMed:28049734, PubMed:24929359). In Purkinje cells, seems to be also involved in the regulation of autophagosome-lysosome fusion upon VEGFA (PubMed:25417698).

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAPK1up-regulates img/direct-activation.png phosphorylation SPHK1 0.547
Publications: 1 Organism: Homo Sapiens
+ MAPK3up-regulates img/direct-activation.png phosphorylation SPHK1 0.59
Publications: 1 Organism: Homo Sapiens
+ ERK1/2up-regulates img/direct-activation.png phosphorylation SPHK1 0.2
Publications: 1 Organism: Homo Sapiens
+ FHL2down-regulates activity img/direct_inhibition.png binding SPHK1 0.434
Publications: 1 Organism: Mus Musculus
Tissue: Heart
+ RPS6KC1up-regulates activity img/direct-activation.png binding SPHK1 0.393
Publications: 1 Organism: Chlorocebus Aethiops
+ KLF14up-regulates quantity by expression img/direct-activation.png transcriptional regulation SPHK1 0.2
Publications: 1 Organism: Homo Sapiens
+ Gbetaup-regulates img/direct-activation.png phosphorylation SPHK1 0.2
Publications: 1 Organism: Homo Sapiens