| Name | CDK12 |
| ID | Q9NYV4 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 727-1020 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK12 | POLR2A | Ser1861 | TPTSPKYsPTSPKYS | phosphorylation up-regulates | 22012619 | SIGNOR-176793 |
| CDK12 | POLR2A | Ser1868 | SPTSPKYsPTSPKYS | phosphorylation up-regulates | 22012619 | SIGNOR-176797 |
| CDK12 | POLR2A | Ser1875 | SPTSPKYsPTSPTYS | phosphorylation up-regulates | 22012619 | SIGNOR-176801 |
| CDK12 | POLR2A | Ser1882 | SPTSPTYsPTTPKYS | phosphorylation up-regulates | 22012619 | SIGNOR-176809 |
| CDK12 | POLR2A | Ser1889 | SPTTPKYsPTSPTYS | phosphorylation up-regulates | 22012619 | SIGNOR-176813 |
| CDK12 | POLR2A | Ser1896 | SPTSPTYsPTSPVYT | phosphorylation up-regulates | 22012619 | SIGNOR-176817 |
| CDK12 | POLR2A | Ser1910 | TPTSPKYsPTSPTYS | phosphorylation up-regulates | 22012619 | SIGNOR-176821 |
| CDK12 | POLR2A | Ser1917 | SPTSPTYsPTSPKYS | phosphorylation up-regulates | 22012619 | SIGNOR-176825 |
| CDK12 | POLR2A | Ser1924 | SPTSPKYsPTSPTYS | phosphorylation up-regulates | 22012619 | SIGNOR-176829 |
| CDK12 | POLR2A | Ser1931 | SPTSPTYsPTSPKGS | phosphorylation up-regulates | 22012619 | SIGNOR-176833 |
| CDK12 | POLR2A | Ser1941 | SPKGSTYsPTSPGYS | phosphorylation up-regulates | 22012619 | SIGNOR-176837 |
| CDK12 | POLR2A | Ser1948 | SPTSPGYsPTSPTYS | phosphorylation up-regulates | 22012619 | SIGNOR-176841 |
| CDK12 | POLR2A | Ser1878 | SPKYSPTsPTYSPTT | phosphorylation up-regulates activity | 22012619 | SIGNOR-176805 |
| CDK12 | PAK2 | Thr134 | LKFYDSNtVKQKYLS | phosphorylation up-regulates activity | 32483448 | SIGNOR-273109 |
| CDK12 | PAK2 | Thr169 | TEAPAVVtEEEDDDE | phosphorylation up-regulates activity | 32483448 | SIGNOR-273110 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1861 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176793 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1868 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176797 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1875 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176801 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1882 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176809 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1889 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176813 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1896 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176817 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1910 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176821 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1917 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176825 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1924 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176829 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1931 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176833 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1941 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176837 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1948 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176841 |
| CDK12 | phosphorylation up-regulates → | POLR2A PSer1878 | phosphorylation up-regulates → | POLR2A | 22012619 | SIGNOR-176805 |
| CDK12 | phosphorylation up-regulates → | PAK2 PThr134 | phosphorylation up-regulates → | PAK2 | 32483448 | SIGNOR-273109 |
| CDK12 | phosphorylation up-regulates → | PAK2 PThr169 | phosphorylation up-regulates → | PAK2 | 32483448 | SIGNOR-273110 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176793 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176797 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176801 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176809 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176813 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176817 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176821 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176825 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176829 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176833 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176837 |
| CDK12 | phosphorylation → up-regulates | POLR2A | SIGNOR-176841 |
| CDK12 | phosphorylation → up-regulates activity | POLR2A | SIGNOR-176805 |
| CDK12 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-273109 |
| CDK12 | phosphorylation → up-regulates activity | PAK2 | SIGNOR-273110 |