| + |
CDK12 | up-regulates 
phosphorylation
|
POLR2A |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176793 |
Ser1861 |
TPTSPKYsPTSPKYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176797 |
Ser1868 |
SPTSPKYsPTSPKYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176801 |
Ser1875 |
SPTSPKYsPTSPTYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176809 |
Ser1882 |
SPTSPTYsPTTPKYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176813 |
Ser1889 |
SPTTPKYsPTSPTYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176817 |
Ser1896 |
SPTSPTYsPTSPVYT |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176821 |
Ser1910 |
TPTSPKYsPTSPTYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176825 |
Ser1917 |
SPTSPTYsPTSPKYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176829 |
Ser1924 |
SPTSPKYsPTSPTYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176833 |
Ser1931 |
SPTSPTYsPTSPKGS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176837 |
Ser1941 |
SPKGSTYsPTSPGYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176841 |
Ser1948 |
SPTSPGYsPTSPTYS |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Publications: |
12 |
Organism: |
Homo Sapiens |
| + |
CDK12 | up-regulates activity
phosphorylation
|
POLR2A |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176805 |
Ser1878 |
SPKYSPTsPTYSPTT |
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
Cyck/cdk12 can activate transcription and phosphorylate ser2 in the ctd of rnapii / phosphorylation of serine at position 2 (ser2) is thought to be responsible for productive transcriptional elongation and synthesis of full-length mature mrna |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK12 | up-regulates activity
phosphorylation
|
PAK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273109 |
Thr134 |
LKFYDSNtVKQKYLS |
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 32483448 |
Mechanistically, CDK12 directly binds to and phosphorylates PAK2 at T134/T169 to activate MAPK signaling pathway |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273110 |
Thr169 |
TEAPAVVtEEEDDDE |
Homo sapiens |
HGC-27 Cell |
| pmid |
sentence |
| 32483448 |
Mechanistically, CDK12 directly binds to and phosphorylates PAK2 at T134/T169 to activate MAPK signaling pathway |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDK7 | up-regulates activity
phosphorylation
|
CDK12 |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275509 |
Thr893 |
SEESRPYtNKVITLW |
|
|
| pmid |
sentence |
| 24662513 |
Although Cdk12/CycK kinase complex lacking T-loop phosphorylation showed some basal activity towards a CTD substrate prephosphorylated at position Ser7, its activity was significantly increased upon coexpression with the CAK from S. cerevisiae (Supplementary Fig. 9a). Mutation of T893 to E to mimic phosphorylation showed no effect on basal kinase activity. Quantitative phosphorylation of a single residue occurred upon coexpression with Cak1, as determined by ESI mass spectrometry (Supplementary Fig. 9b). |
|
| Publications: |
1 |
| + |
CAK complex | up-regulates activity
phosphorylation
|
CDK12 |
0.519 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275510 |
Thr893 |
SEESRPYtNKVITLW |
|
|
| pmid |
sentence |
| 24662513 |
Although Cdk12/CycK kinase complex lacking T-loop phosphorylation showed some basal activity towards a CTD substrate prephosphorylated at position Ser7, its activity was significantly increased upon coexpression with the CAK from S. cerevisiae (Supplementary Fig. 9a). Mutation of T893 to E to mimic phosphorylation showed no effect on basal kinase activity. Quantitative phosphorylation of a single residue occurred upon coexpression with Cak1, as determined by ESI mass spectrometry (Supplementary Fig. 9b). |
|
| Publications: |
1 |
| + |
CDK12 | form complex 
binding
|
CyclinK/CDK12 |
0.941 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176789 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22012619 |
We identified a 70-kda cyclin k (cyck) that binds cdk12 and cdk13 to form two different complexes (cyck/cdk12 or cyck/cdk13) in human cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDK12
- 
- 