Entity Details

Name CDK12
ID Q9NYV4
Role substrate
Enzymatic Domains
Protein kinase 727-1020
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CDK7CDK12Thr893
View in OncoXplorer
SEESRPYtNKVITLWphosphorylation
up-regulates activity		24662513SIGNOR-275509
CAK complexCDK12Thr893
View in OncoXplorer
SEESRPYtNKVITLWphosphorylation
up-regulates activity		24662513SIGNOR-275510
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CDK7phosphorylation
up-regulates
→
CDK12
PThr893		phosphorylation
up-regulates
→		CDK1224662513SIGNOR-275509
CAK complexphosphorylation
up-regulates
→
CDK12
PThr893		phosphorylation
up-regulates
→		CDK1224662513SIGNOR-275510
Regulator Mechanism/Effect Target SIGNOR-ID
CDK7phosphorylation
→
up-regulates activity 		CDK12SIGNOR-275509
CAK complexphosphorylation
→
up-regulates activity 		CDK12SIGNOR-275510