| Name | PLK2 |
| ID | Q9NYY3 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 82-334 PROSITE-ProRule
POLO box 1 503-581 PROSITE-ProRule
POLO box 2 601-685 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK2 | TP73 | Ser48 | VVGGTDSsMDVFHLE | phosphorylation down-regulates activity | 26625870 | SIGNOR-278218 |
| PLK2 | TP53 | – | phosphorylation up-regulates activity | 29448085 | SIGNOR-278980 | |
| PLK2 | APP | Thr743 | VEVDAAVtPEERHLS | phosphorylation up-regulates activity | 28257888 | SIGNOR-279424 |
| PLK2 | NPM1 | Ser4 | sMDMDMSP | phosphorylation up-regulates | 15190079 | SIGNOR-125720 |
| PLK2 | LRPAP1 | – | phosphorylation up-regulates activity | 21382555 | SIGNOR-279476 | |
| PLK2 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-182155 |
| PLK2 | SNCB | Ser118 | LMEPEGEsYEDPPQE | phosphorylation down-regulates activity | 19889641 | SIGNOR-189049 |
| PLK2 | FBXW7 | Ser176 | KRKLDHGsEVRSFSL | phosphorylation down-regulates | 22399798 | SIGNOR-196448 |
| PLK2 | CENPJ | Ser589 | EQAADEIsFSSNSSF | phosphorylation up-regulates | 20531387 | SIGNOR-165999 |
| PLK2 | CENPJ | Ser595 | ISFSSNSsFVLKILE | phosphorylation up-regulates | 20531387 | SIGNOR-166003 |
| PLK2 | RAPGEF2 | – | phosphorylation up-regulates activity | 21382555 | SIGNOR-280066 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK2 | phosphorylation up-regulates → | TP73 PSer48 | phosphorylation down-regulates ⊣ | TP73 | 26625870 | SIGNOR-278218 |
| PLK2 | phosphorylation up-regulates → | APP PThr743 | phosphorylation up-regulates → | APP | 28257888 | SIGNOR-279424 |
| PLK2 | phosphorylation up-regulates → | NPM1 PSer4 | phosphorylation up-regulates → | NPM1 | 15190079 | SIGNOR-125720 |
| PLK2 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-182155 |
| PLK2 | phosphorylation up-regulates → | SNCB PSer118 | phosphorylation down-regulates ⊣ | SNCB | 19889641 | SIGNOR-189049 |
| PLK2 | phosphorylation up-regulates → | FBXW7 PSer176 | phosphorylation down-regulates ⊣ | FBXW7 | 22399798 | SIGNOR-196448 |
| PLK2 | phosphorylation up-regulates → | CENPJ PSer589 | phosphorylation up-regulates → | CENPJ | 20531387 | SIGNOR-165999 |
| PLK2 | phosphorylation up-regulates → | CENPJ PSer595 | phosphorylation up-regulates → | CENPJ | 20531387 | SIGNOR-166003 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK2 | phosphorylation → down-regulates activity | TP73 | SIGNOR-278218 |
| PLK2 | phosphorylation → up-regulates activity | TP53 | SIGNOR-278980 |
| PLK2 | phosphorylation → up-regulates activity | APP | SIGNOR-279424 |
| PLK2 | phosphorylation → up-regulates | NPM1 | SIGNOR-125720 |
| PLK2 | phosphorylation → up-regulates activity | LRPAP1 | SIGNOR-279476 |
| PLK2 | phosphorylation → down-regulates activity | SNCA | SIGNOR-182155 |
| PLK2 | phosphorylation → down-regulates activity | SNCB | SIGNOR-189049 |
| PLK2 | phosphorylation down-regulates | FBXW7 | SIGNOR-196448 |
| PLK2 | phosphorylation → up-regulates | CENPJ | SIGNOR-165999 |
| PLK2 | phosphorylation → up-regulates | CENPJ | SIGNOR-166003 |
| PLK2 | phosphorylation → up-regulates activity | RAPGEF2 | SIGNOR-280066 |