3.0
Summary
| Name |  PLK2View Modifications |
| Full Name | Serine/threonine-protein kinase PLK2 |
| Synonyms | Polo-like kinase 2, PLK-2, hPlk2, Serine/threonine-protein kinase SNK, hSNK, Serum-inducible kinase | SNK |
| Primary ID | Q9NYY3 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK2 | down-regulates activity 
phosphorylation
|
SNCB | 0.253 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK2 | down-regulates activity
phosphorylation
|
SNCA | 0.495 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK2 | down-regulates
phosphorylation
|
FBXW7 | 0.501 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK2 | up-regulates 
phosphorylation
|
NPM1 | 0.515 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLK2 | up-regulates
phosphorylation
|
CENPJ | 0.556 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | VPS18 | down-regulates quantity by destabilization
ubiquitination
|
PLK2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |