| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NLK | LEF1 | – | phosphorylation down-regulates quantity | 16714285 | SIGNOR-271596 | |
| CSNK2A1 | LEF1 | – | phosphorylation up-regulates | 2861485 | SIGNOR-23958 | |
| NLK | LEF1 | Thr155 | SHAVHPLtPLITYSD | phosphorylation down-regulates | 12556497 | SIGNOR-97812 |
| CSNK2A1 | LEF1 | – | phosphorylation up-regulates | 15747065 | SIGNOR-134500 | |
| CSNK1E | LEF1 | – | phosphorylation down-regulates | 15747065 | SIGNOR-134497 | |
| CSNK2A1 | LEF1 | – | phosphorylation up-regulates | 19623618 | SIGNOR-187209 | |
| CSNK1D | LEF1 | – | phosphorylation down-regulates | 15747065 | SIGNOR-134494 | |
| NLK | LEF1 | Ser166 | TYSDEHFsPGSHPSH | phosphorylation down-regulates | 12556497 | SIGNOR-97808 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| NLK | phosphorylation up-regulates → | LEF1 PThr155 | phosphorylation down-regulates ⊣ | LEF1 | 12556497 | SIGNOR-97812 |
| NLK | phosphorylation up-regulates → | LEF1 PSer166 | phosphorylation down-regulates ⊣ | LEF1 | 12556497 | SIGNOR-97808 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| NLK | phosphorylation → down-regulates quantity | LEF1 | SIGNOR-271596 |
| CSNK2A1 | phosphorylation → up-regulates | LEF1 | SIGNOR-23958 |
| NLK | phosphorylation down-regulates | LEF1 | SIGNOR-97812 |
| CSNK2A1 | phosphorylation → up-regulates | LEF1 | SIGNOR-134500 |
| CSNK1E | phosphorylation down-regulates | LEF1 | SIGNOR-134497 |
| CSNK2A1 | phosphorylation → up-regulates | LEF1 | SIGNOR-187209 |
| CSNK1D | phosphorylation down-regulates | LEF1 | SIGNOR-134494 |
| NLK | phosphorylation down-regulates | LEF1 | SIGNOR-97808 |
