Summary

Name LEF1
Full Name Lymphoid enhancer-binding factor 1
Synonyms LEF-1, T cell-specific transcription factor 1-alpha, TCF1-alpha
Primary ID Q9UJU2
Links - -
Type protein
Relations 35
Pathways Colorectal Carcinoma, Hepatocellular Tumor, Satellite: FST transcriptional regulation, T-Lymphocyte: IL4 and its transcriptional regulation, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
Function Transcription factor that binds DNA in a sequence-specific manner (PubMed:2010090). Participates in the Wnt signaling pathway (By similarity). Activates transcription of target genes in the presence of CTNNB1 and EP300 (By similarity). PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (PubMed:11266540). Regulates T-cell receptor alpha enhancer function (PubMed:19653274). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (By similarity). May play a role in hair cell differentiation and follicle morphogenesis (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation LEF1 0.75
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png transcriptional regulation NCAM1 0.281
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation LEF1 0.309
Publications: 3 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL4 0.362
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Survival 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor, WNT Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PITX2 0.707
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling, WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FST 0.286
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png LEF1 0.465
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ up-regulates activity img/direct-activation.png binding LEF1 0.441
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling and Myogenesis
+ up-regulates activity img/direct-activation.png binding LEF1 0.914
Publications: 3 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3, WNT Signaling and Myogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ELANE 0.261
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CLDN2 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:WNT Signaling
+ down-regulates activity img/direct_inhibition.png binding LEF1 0.673
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png binding ALX4 0.459
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPA 0.358
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png phosphorylation LEF1 0.75
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LEF1 0.273
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CCND1 0.584
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png LEF1 0.534
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYC 0.622
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OCA2 0.257
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LEF1 0.254
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination LEF1 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png LEF1 0.677
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYF5 0.256
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
Pathways:WNT Signaling and Myogenesis
+ up-regulates img/indirect-activation.png transcriptional regulation LEF1 0.606
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor
+ down-regulates img/direct_inhibition.png binding LEF1 0.617
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Colorectal Carcinoma, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DSG4 0.294
Publications: 1 Organism: Homo Sapiens