| Name | ALK |
| ID | Q9UM73 |
| Role | kinase |
| Enzymatic Domains |
MAM 1 264-427 PROSITE-ProRule
LDL-receptor class A 437-473
MAM 2 478-636 PROSITE-ProRule
Protein kinase 1116-1392 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ALK | MAPT | – | phosphorylation up-regulates quantity | 33452442 | SIGNOR-279318 | |
| ALK | SFPQ | Tyr293 | RRPGEKTyTQRCRLF | phosphorylation down-regulates | 17537995 | SIGNOR-155298 |
| ALK | SHC1 | – | phosphorylation up-regulates | 12185581 | SIGNOR-91534 | |
| ALK | ATIC | Tyr104 | RVVACNLyPFVKTVA | phosphorylation up-regulates activity | 18845790 | SIGNOR-276171 |
| ALK | STAT3 | – | phosphorylation up-regulates activity | 11850821 | SIGNOR-279319 | |
| ALK | GSK3B | – | phosphorylation up-regulates activity | 33479180 | SIGNOR-280180 | |
| ALK | CDK9 | Tyr19 | FCDEVSKyEKLAKIG | phosphorylation up-regulates activity | 36253486 | SIGNOR-277607 |
| ALK | GRB2 | Tyr160 | QVPQQPTyVQALFDF | phosphorylation unknown | 20554525 | SIGNOR-247142 |
| ALK | HES1 | – | phosphorylation up-regulates activity | 35640677 | SIGNOR-280181 | |
| ALK | SHC3 | – | phosphorylation up-regulates | 12185581 | SIGNOR-91537 | |
| ALK | PIK3R3 | – | phosphorylation up-regulates activity | 27322022 | SIGNOR-253217 | |
| ALK | ALK | Tyr1278 | FGMARDIyRASYYRK | phosphorylation up-regulates activity | 15938644 | SIGNOR-250575 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ALK | phosphorylation up-regulates → | SFPQ PTyr293 | phosphorylation down-regulates ⊣ | SFPQ | 17537995 | SIGNOR-155298 |
| ALK | phosphorylation up-regulates → | ATIC PTyr104 | phosphorylation up-regulates → | ATIC | 18845790 | SIGNOR-276171 |
| ALK | phosphorylation up-regulates → | CDK9 PTyr19 | phosphorylation up-regulates → | CDK9 | 36253486 | SIGNOR-277607 |
| ALK | phosphorylation up-regulates → | GRB2 PTyr160 | phosphorylation down-regulates ⊣ | GRB2 | 20554525 | SIGNOR-247142 |
| ALK | phosphorylation up-regulates → | ALK PTyr1278 | phosphorylation up-regulates → | ALK | 15938644 | SIGNOR-250575 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ALK | phosphorylation → up-regulates quantity | MAPT | SIGNOR-279318 |
| ALK | phosphorylation down-regulates | SFPQ | SIGNOR-155298 |
| ALK | phosphorylation → up-regulates | SHC1 | SIGNOR-91534 |
| ALK | phosphorylation → up-regulates activity | ATIC | SIGNOR-276171 |
| ALK | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279319 |
| ALK | phosphorylation → up-regulates activity | GSK3B | SIGNOR-280180 |
| ALK | phosphorylation → up-regulates activity | CDK9 | SIGNOR-277607 |
| ALK | phosphorylation → unknown | GRB2 | SIGNOR-247142 |
| ALK | phosphorylation → up-regulates activity | HES1 | SIGNOR-280181 |
| ALK | phosphorylation → up-regulates | SHC3 | SIGNOR-91537 |
| ALK | phosphorylation → up-regulates activity | PIK3R3 | SIGNOR-253217 |
| ALK | phosphorylation → up-regulates activity | ALK | SIGNOR-250575 |