4.0
Summary
| Name |  ALKView Modifications |
| Full Name | ALK tyrosine kinase receptor |
| Synonyms | Anaplastic lymphoma kinase |
| Primary ID | Q9UM73 |
| Links |  -  -  |
| Type | protein |
| Relations | 25 |
| Inhibitors | 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine; 2-[[2-[[1-[2-(dimethylamino)-1-oxoethyl]-5-methoxy-2,3-dihydroindol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide; crizotinib; alectinib; ceritinib |
| Function | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. Thinness gene involved in the resistance to weight gain |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ALK | up-regulates activity 
phosphorylation
|
ATIC | 0.378 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates activity
phosphorylation
|
ALK | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ALK |
phosphorylation
|
GRB2 | 0.465 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates activity
phosphorylation
|
CDK9 | 0.295 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ALK | down-regulates 
phosphorylation
|
SFPQ | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates
phosphorylation
|
SHC1 | 0.454 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine | down-regulates
chemical inhibition
|
ALK | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 2-[[2-[[1-[2-(dimethylamino)-1-oxoethyl]-5-methoxy-2,3-dihydroindol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide | down-regulates activity
chemical inhibition
|
ALK | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ALK | up-regulates
phosphorylation
|
SHC3 | 0.438 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates activity
phosphorylation
|
PIK3R3 | 0.38 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | crizotinib | down-regulates
chemical inhibition
|
ALK | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates quantity
phosphorylation
|
MAPT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTN | up-regulates
binding
|
ALK | 0.547 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | alectinib | down-regulates
chemical inhibition
|
ALK | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | crizotinib | down-regulates activity
chemical inhibition
|
ALK | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ALK | up-regulates activity
phosphorylation
|
GSK3B | 0.248 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates activity
phosphorylation
|
HES1 | 0.266 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPRZ1 | down-regulates
dephosphorylation
|
ALK | 0.544 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates activity
phosphorylation
|
STAT3 | 0.44 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine | down-regulates activity
chemical inhibition
|
ALK | 0.8 |
| Publications: | 1 | Organism: | In Vitro | |
| + | ALK | up-regulates
binding
|
STAT3 | 0.44 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ceritinib | down-regulates activity
chemical inhibition
|
ALK | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates
binding
|
PLCG1 | 0.546 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PTPRB | down-regulates
dephosphorylation
|
ALK | 0.334 |
| Publications: | 1 | Organism: | Homo Sapiens | |